Detailed information NTG0639316

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: LXA46_RS02450
• Genome accession: NZ_CP089948
• Coordinates: 505819..506556 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae TIGR4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 500819..511556

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LXA46_RS02420 (LXA46_02415)	-	502151..502438 (-)	288	WP_000777760.1	hypothetical protein	-
LXA46_RS02425 (LXA46_02420)	-	502448..502858 (-)	411	WP_001278301.1	HIT family protein	-
LXA46_RS02430 (LXA46_02425)	pptA	502926..503657 (+)	732	WP_000889924.1	ABC transporter ATP-binding protein	Regulator
LXA46_RS02435 (LXA46_02430)	-	503654..504703 (+)	1050	WP_000653779.1	ABC transporter permease	-
LXA46_RS02440 (LXA46_02435)	-	504871..505200 (-)	330	WP_000132572.1	hypothetical protein	-
LXA46_RS02445 (LXA46_02440)	-	505476..505814 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
LXA46_RS02450 (LXA46_02445)	comE/blpR	505819..506556 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
LXA46_RS02455 (LXA46_02450)	-	506570..507910 (+)	1341	WP_001017646.1	sensor histidine kinase	-
LXA46_RS02460 (LXA46_02455)	blpC	507981..508109 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
LXA46_RS02465 (LXA46_02460)	-	508166..509527 (-)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
LXA46_RS11000	comA/nlmT	509538..510185 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
LXA46_RS11005	comA/nlmT	510201..511214 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=639316 LXA46_RS02450 WP_001219120.1 505819..506556(+) (comE/blpR) [Streptococcus pneumoniae TIGR4]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=639316 LXA46_RS02450 WP_001219120.1 505819..506556(+) (comE/blpR) [Streptococcus pneumoniae TIGR4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363