Detailed information NTG0063311

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: T15_RS06715
• Genome accession: NC_022665
• Coordinates: 1342562..1344799 (-)
• Length: 745 a.a.
• NCBI ID: WP_023370710.1
• Uniprot ID: A0A822VNS2
• Organism: Streptococcus suis T15
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1337562..1349799

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
T15_RS06690 (T15_1324)	tmk	1337678..1338316 (-)	639	WP_023370703.1	dTMP kinase	-
T15_RS06695 (T15_1325)	-	1338491..1339357 (+)	867	WP_023370705.1	YitT family protein	-
T15_RS06700 (T15_1326)	-	1339394..1340665 (-)	1272	WP_002935355.1	toxic anion resistance protein	-
T15_RS06705 (T15_1327)	-	1340671..1341498 (-)	828	WP_023370707.1	hypothetical protein	-
T15_RS06710 (T15_1328)	-	1341592..1342248 (-)	657	WP_023370708.1	CBS domain-containing protein	-
T15_RS11890	-	1342431..1342553 (-)	123	Protein_1287	IS982 family transposase	-
T15_RS06715 (T15_1329)	comEC/celB	1342562..1344799 (-)	2238	WP_023370710.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
T15_RS06720 (T15_1330)	comEA/celA/cilE	1344783..1345445 (-)	663	WP_023370712.1	helix-hairpin-helix domain-containing protein	Machinery gene
T15_RS06725 (T15_1331)	-	1345512..1346258 (-)	747	WP_023370714.1	lysophospholipid acyltransferase family protein	-
T15_RS06730 (T15_1332)	-	1346404..1347849 (+)	1446	WP_023370716.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
T15_RS06735 (T15_1333)	-	1348001..1348801 (+)	801	WP_023370718.1	ABC transporter ATP-binding protein	-
T15_RS06740 (T15_1334)	-	1348798..1349727 (+)	930	WP_023370720.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 745 a.a.
• Molecular weight: 84161.27 Da
• Isoelectric Point: 8.9144

>NTDB_id=63311 T15_RS06715 WP_023370710.1 1342562..1344799(-) (comEC/celB) [Streptococcus suis T15]
MSRLSKLPCQPIHLALLAVAAYFVVHSFSLLTMGLLSLLLLVFGFRQGKTVFIRTLPLIALCGLFFGYQKVQWERADQLA
PEQVTTVQVIPDTIEVNGDSLSFRGRADGQTYQVFYKLTSQEEQTYFQKLTGLVQLEVEAEISLPAGQRNFKGFDYQAYL
KTQGIYRTVKITAIKKIVPVQSWNVFDWLSNWRRQALVYVKTNFPVPMSHYMTGLLFGDLDSDFDQMSDLYSSLGIIHLF
ALSGMQVGFFIDKFRWILLRLGLTKETVDKLQIPFSLVYASLTGFSVSVVRSLVQKILGNLGLRKLDNFAVTVFVCLLIL
PRFLLTAGGVLTFTYAFLLTVFDFEDLGQVKKAAVESLSISLGILPVLMTYFYAFQPLSILLTFAFSFVFDVLLLPGLSV
IFLLSPIVKITWVNGFFVFMEKIIVWVADLGLRPWILGKPSELVLLLLLVSLFLLYDFHRRKKWLLGLSLVLALLFFITK
HPLENEVTVVDIGQGDSIFLRDMRGRTVLIDVGGRVDFAAKEAWQERSRQANAERTLIPYLHSRGVDRIDSLVLTHTDTD
HVGDVLEVAKQVQIGRIVVSPGSLTVPDFVATLKKINVPVHVVKVGDRLPIFDSYLEVLYPDGTGDGGNNDSIVLYGRLL
ETNFLFTGDLEQGELDLIATYPNLPVDVLKAGHHGSKGSSYPEFLDHIGAKIALISAGKNNRYKHPHQETLDRFDSRNIQ
VYRTDQQGAIRFRGWKEWRIETVRR

Nucleotide

• Length: 2238 bp

>NTDB_id=63311 T15_RS06715 WP_023370710.1 1342562..1344799(-) (comEC/celB) [Streptococcus suis T15]
ATGTCACGGTTGAGTAAGCTCCCCTGCCAGCCCATCCACTTGGCTCTTTTGGCGGTGGCAGCCTACTTTGTAGTCCACTC
TTTTTCCCTCTTGACAATGGGCCTGCTGAGTTTGTTGTTGCTGGTCTTTGGATTTCGACAAGGTAAGACAGTTTTCATCA
GAACGCTGCCGCTTATAGCCTTATGTGGTCTGTTTTTCGGCTACCAAAAGGTCCAATGGGAGCGGGCAGACCAGTTAGCC
CCAGAGCAAGTGACGACTGTGCAGGTCATTCCAGATACGATTGAAGTCAACGGGGACAGCCTGTCCTTCCGCGGTCGGGC
TGACGGACAAACCTATCAGGTTTTCTATAAATTAACCAGTCAGGAGGAACAGACCTATTTTCAAAAGCTGACAGGTTTGG
TCCAGCTTGAAGTGGAAGCAGAGATCAGTCTGCCAGCTGGTCAGCGGAATTTCAAGGGTTTTGACTATCAGGCCTACCTG
AAAACACAGGGTATTTATCGGACGGTCAAGATTACGGCAATCAAGAAGATTGTCCCAGTCCAGTCTTGGAATGTCTTTGA
CTGGTTGTCAAACTGGCGGAGGCAGGCTTTGGTTTATGTCAAAACCAATTTTCCGGTTCCCATGAGCCACTACATGACAG
GGCTCTTGTTTGGGGACTTGGATAGTGATTTTGACCAGATGAGTGACCTCTATTCCAGTTTGGGTATCATTCATCTCTTT
GCCCTGTCTGGTATGCAGGTGGGCTTTTTCATCGACAAGTTTCGCTGGATTTTACTGCGTTTGGGCTTGACCAAAGAAAC
GGTTGATAAATTACAAATTCCCTTTTCCCTTGTCTATGCGAGCTTGACAGGTTTTTCCGTATCGGTGGTGCGGTCTTTGG
TTCAAAAAATTTTGGGTAATCTGGGCTTGCGGAAGTTGGATAACTTTGCGGTGACAGTTTTTGTCTGTCTGTTGATACTG
CCCCGATTTCTGCTGACAGCTGGTGGTGTCCTGACCTTTACCTATGCTTTTTTGCTGACGGTTTTTGATTTTGAGGACTT
GGGGCAGGTCAAAAAGGCTGCGGTGGAAAGTCTCAGTATTTCACTTGGGATTTTGCCAGTGCTCATGACCTATTTCTATG
CCTTTCAGCCCCTGTCTATCCTCTTGACCTTTGCCTTTTCTTTTGTCTTTGATGTCCTACTCTTGCCAGGCTTGTCAGTC
ATTTTTCTCCTGTCGCCAATCGTCAAGATTACTTGGGTCAACGGATTTTTTGTCTTTATGGAAAAAATCATTGTCTGGGT
GGCGGATTTGGGATTGCGACCTTGGATACTGGGCAAGCCGTCTGAGCTGGTCCTTTTGCTCTTGCTGGTCAGCCTCTTCT
TACTCTACGATTTCCACAGGAGAAAGAAATGGCTTCTAGGACTGAGCTTGGTCCTCGCTCTGCTATTTTTCATAACCAAA
CACCCGCTGGAAAACGAGGTGACGGTGGTGGACATCGGGCAGGGGGACAGCATCTTTTTGCGGGATATGCGGGGGCGGAC
GGTCCTGATTGATGTGGGCGGACGAGTTGATTTTGCGGCCAAGGAAGCGTGGCAGGAGCGGTCTCGGCAGGCAAATGCAG
AGCGGACTTTGATTCCCTATCTGCATAGTCGGGGTGTGGATAGGATTGATAGTTTAGTCCTGACCCACACCGACACAGAC
CATGTGGGGGATGTGCTGGAAGTGGCTAAGCAGGTGCAAATTGGTCGGATTGTCGTGTCGCCAGGAAGTCTGACGGTGCC
TGACTTTGTAGCAACTCTGAAAAAAATCAATGTGCCTGTCCATGTGGTAAAAGTGGGCGACCGCCTACCAATTTTTGACT
CCTATCTGGAGGTCCTCTATCCAGATGGGACAGGAGACGGTGGTAATAATGACTCTATTGTTCTCTACGGTCGCTTGTTG
GAAACCAACTTTCTCTTTACAGGAGATTTGGAGCAAGGGGAGTTGGACTTGATAGCAACCTATCCCAACCTGCCTGTCGA
TGTCCTCAAGGCTGGTCACCATGGCTCCAAAGGTTCTTCCTATCCCGAATTTTTAGACCATATCGGTGCCAAGATTGCCT
TGATATCTGCTGGAAAAAATAACCGCTACAAGCATCCTCATCAAGAAACCTTGGACCGCTTTGACAGTCGGAATATCCAA
GTCTATCGTACCGACCAGCAAGGAGCCATCCGCTTCCGAGGTTGGAAGGAGTGGAGGATTGAAACGGTGAGGAGGTAA

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (28-175)

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-698)

• Competence protein (Competence) (215-461)

3D structure

• AlphaFold DB: A0A822VNS2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	54.24	99.732	0.541
comEC/celB	Streptococcus mitis NCTC 12261	53.171	99.463	0.529
comEC/celB	Streptococcus pneumoniae TIGR4	52.291	99.597	0.521
comEC/celB	Streptococcus pneumoniae Rx1	52.022	99.597	0.518
comEC/celB	Streptococcus pneumoniae D39	52.022	99.597	0.518
comEC/celB	Streptococcus pneumoniae R6	52.022	99.597	0.518
comEC	Lactococcus lactis subsp. cremoris KW2	49.398	100	0.495