Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   N4T37_RS12245 Genome accession   NZ_CP104350
Coordinates   2069532..2070206 (+) Length   224 a.a.
NCBI ID   WP_000161506.1    Uniprot ID   G1CBK2
Organism   Acinetobacter baumannii strain 2021CK-01333     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2064532..2075206
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  N4T37_RS12230 (N4T37_12225) - 2064589..2065836 (+) 1248 WP_000489712.1 MFS transporter -
  N4T37_RS12235 (N4T37_12230) - 2066382..2067686 (+) 1305 WP_000362909.1 DcaP family trimeric outer membrane transporter -
  N4T37_RS12240 (N4T37_12235) - 2067868..2069517 (+) 1650 WP_031975152.1 phosphoethanolamine transferase -
  N4T37_RS12245 (N4T37_12240) ciaR 2069532..2070206 (+) 675 WP_000161506.1 DNA-binding response regulator PmrA Regulator
  N4T37_RS12250 (N4T37_12245) - 2070232..2071566 (+) 1335 WP_000559381.1 two-component system sensor histidine kinase PmrB -
  N4T37_RS12255 (N4T37_12250) - 2071567..2072265 (-) 699 WP_000184466.1 phosphatase PAP2 family protein -
  N4T37_RS12260 (N4T37_12255) - 2072418..2073605 (-) 1188 WP_024437369.1 ammonium transporter -
  N4T37_RS12265 (N4T37_12260) - 2073908..2074792 (-) 885 Protein_1980 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25562.50 Da        Isoelectric Point: 5.3246

>NTDB_id=628756 N4T37_RS12245 WP_000161506.1 2069532..2070206(+) (ciaR) [Acinetobacter baumannii strain 2021CK-01333]
MTKILMIEDDFMIAESTITLLQYHQFEVEWVNNGLDGLAQLAKTKFDLILLDLGLPMMDGMQVLKQIRQRAATPVLIISA
RDQLQNRVDGLNLGADDYLIKPYEFDELLARIHALLRRTGVEAQLASQDQLLESGDLVLNVEQHIATFKGQRIDLSNREW
AILIPLMTHPNKIFSKANLEDKLYDFDSDVTSNTIEVYVHHLRAKLGKDFIRTIRGLGYRLGQS

Nucleotide


Download         Length: 675 bp        

>NTDB_id=628756 N4T37_RS12245 WP_000161506.1 2069532..2070206(+) (ciaR) [Acinetobacter baumannii strain 2021CK-01333]
ATGACAAAAATCTTGATGATTGAAGATGATTTTATGATTGCAGAATCAACGATCACGTTGCTGCAATATCATCAATTTGA
GGTGGAATGGGTCAATAACGGTTTAGATGGTTTGGCTCAATTGGCGAAGACTAAATTTGATCTTATTCTTTTGGATTTAG
GATTGCCTATGATGGATGGTATGCAAGTTTTAAAGCAGATCCGTCAAAGAGCAGCAACACCAGTATTAATTATTTCTGCC
CGAGATCAATTACAAAACCGTGTCGATGGTTTAAATTTGGGTGCAGATGATTATTTAATTAAACCTTATGAGTTTGATGA
GTTGCTTGCCCGTATTCATGCATTACTACGCCGTACTGGAGTAGAAGCTCAACTTGCGAGTCAAGATCAACTATTAGAAA
GTGGTGATCTGGTTTTAAATGTTGAACAGCATATTGCGACGTTTAAAGGCCAACGCATTGATTTATCAAATCGTGAATGG
GCAATCTTAATTCCACTTATGACTCACCCAAATAAAATCTTTTCTAAAGCCAACTTAGAAGATAAGTTATATGATTTTGA
TAGTGATGTGACCAGTAATACTATTGAAGTATATGTTCACCATTTAAGAGCGAAGCTGGGTAAAGATTTTATTCGAACCA
TCCGAGGACTGGGCTACCGTTTGGGGCAATCATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(150-221)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G1CBK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.053

100

0.384
  ciaR Streptococcus pneumoniae D39

38.053

100

0.384
  ciaR Streptococcus pneumoniae R6

38.053

100

0.384
  ciaR Streptococcus pneumoniae TIGR4

38.053

100

0.384
  ciaR Streptococcus mutans UA159

37.004

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.526

100

0.362