Detailed information NTG0061814

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SCR2_RS02845
• Genome accession: NC_022245
• Coordinates: 557899..558645 (-)
• Length: 248 a.a.
• NCBI ID: WP_041786327.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. pharyngis C818
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 552899..563645

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCR2_RS02830 (SCR2_0560)	-	554936..556296 (+)	1361	Protein_545	bacteriocin secretion accessory protein	-
SCR2_RS02835 (SCR2_0561)	-	556393..556542 (+)	150	WP_003037249.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCR2_RS10595	-	556587..557408 (-)	822	WP_235043796.1	sensor histidine kinase	-
SCR2_RS02845 (SCR2_0563)	comE/blpR	557899..558645 (-)	747	WP_041786327.1	response regulator transcription factor	Regulator
SCR2_RS02850 (SCR2_0564)	-	558814..559527 (-)	714	WP_020997680.1	CPBP family intramembrane glutamic endopeptidase	-
SCR2_RS02855 (SCR2_0565)	-	559759..559980 (+)	222	WP_006267535.1	Blp family class II bacteriocin	-
SCR2_RS02865 (SCR2_0567)	-	560657..560977 (+)	321	WP_006267159.1	hypothetical protein	-
SCR2_RS02870 (SCR2_0568)	-	560985..561218 (+)	234	WP_003025420.1	garvicin Q family class II bacteriocin	-
SCR2_RS02875 (SCR2_0569)	-	561270..561560 (+)	291	WP_006267076.1	bacteriocin immunity protein	-
SCR2_RS02880 (SCR2_0570)	-	561710..562030 (+)	321	WP_006267110.1	hypothetical protein	-
SCR2_RS02885 (SCR2_0571)	-	562475..563524 (+)	1050	WP_020997684.1	thioredoxin family protein	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28742.18 Da
• Isoelectric Point: 7.0486

>NTDB_id=61814 SCR2_RS02845 WP_041786327.1 557899..558645(-) (comE/blpR) [Streptococcus constellatus subsp. pharyngis C818]
MNIFILEDDLTQQYYMETIVEEIIEKHHLQYHHFEVVGKPKQLLEAISEKGSHQIFFLDIEIKTEEEKGLDVAKKIREID
PYAIIVFVTSHSELMPTAFKLQVGALDYLDKSLSKEIFKKRIETALLHTESLTGKGLADDALLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLLDILKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLISRAKIKGLTEA
IAALHRRE

Nucleotide

• Length: 747 bp

>NTDB_id=61814 SCR2_RS02845 WP_041786327.1 557899..558645(-) (comE/blpR) [Streptococcus constellatus subsp. pharyngis C818]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCATCTTCAATATCATCATTTTGAAGTTGTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGATTTTCTTTTTAGACATTGAAATCAAAACCGAGGAAGAAAAGGGCTTAGACGTTGCTAAAAAGATACGCGAGATAGAT
CCTTATGCCATCATTGTCTTTGTAACCAGTCATTCTGAATTGATGCCTACAGCGTTTAAGCTGCAAGTGGGTGCCCTTGA
TTATCTTGACAAATCGTTATCAAAAGAAATCTTTAAAAAACGGATCGAAACTGCACTGCTACATACTGAAAGCCTAACAG
GTAAAGGGCTGGCAGACGATGCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCATTTAAAGATATTCTTTAT
ATTGAAACTTCCTCTCGTCCTCACCGCTTAGTTCTTTACACACATAGAGGACGTACGGAATTTACTGCTAATCTTTTAGA
TATTTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGCTCCTTTGTTGTTAATCCAGCTAATGTCCATCAAGTGGATA
AGGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTATTTCCAGAGCAAAAATAAAAGGGTTAACAGAAGCC
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.202	99.597	0.5
comE/comE1	Streptococcus equinus JB1	44.304	95.565	0.423
comE	Streptococcus pneumoniae Rx1	37.398	99.194	0.371
comE	Streptococcus pneumoniae D39	37.398	99.194	0.371
comE	Streptococcus pneumoniae R6	37.398	99.194	0.371
comE	Streptococcus pneumoniae TIGR4	37.398	99.194	0.371
comE	Streptococcus mitis NCTC 12261	37.398	99.194	0.371
comE	Streptococcus mitis SK321	37.398	99.194	0.371
comE	Streptococcus infantis strain Atu-4	36.992	99.194	0.367