Detailed information NTG0061453

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SCRE_RS02275
• Genome accession: NC_022236
• Coordinates: 441300..441974 (-)
• Length: 224 a.a.
• NCBI ID: WP_020997643.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. pharyngis C232
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	433991..444059	441300..441974	within	0

Gene organization within MGE regions

Location: 433991..444059

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCRE_RS02230 (SCRE_0442)	comFA/cflA	433991..435292 (+)	1302	WP_020997640.1	DEAD/DEAH box helicase	Machinery gene
SCRE_RS02235 (SCRE_0443)	-	435289..435954 (+)	666	WP_006267632.1	ComF family protein	-
SCRE_RS02240 (SCRE_0444)	hpf	436033..436575 (+)	543	WP_006267638.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
SCRE_RS02245 (SCRE_0445)	rsmD	436772..437311 (+)	540	WP_020997641.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SCRE_RS02250 (SCRE_0446)	coaD	437301..437798 (+)	498	WP_006267255.1	pantetheine-phosphate adenylyltransferase	-
SCRE_RS02255 (SCRE_0447)	sepM	437779..438834 (+)	1056	WP_020997642.1	SepM family pheromone-processing serine protease	Regulator
SCRE_RS02260 (SCRE_0448)	-	439121..439678 (+)	558	WP_006267391.1	YutD family protein	-
SCRE_RS02265 (SCRE_0449)	rlmN	439712..440794 (+)	1083	WP_006269861.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SCRE_RS02270 (SCRE_0450)	-	440787..441305 (+)	519	WP_003070167.1	VanZ family protein	-
SCRE_RS02275 (SCRE_0451)	cclA/cilC	441300..441974 (-)	675	WP_020997643.1	prepilin peptidase	Machinery gene
SCRE_RS02280 (SCRE_0452)	-	442125..442652 (+)	528	WP_006267546.1	Dps family protein	-
SCRE_RS02285 (SCRE_0454)	-	442869..444059 (-)	1191	WP_006267506.1	site-specific integrase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25312.66 Da
• Isoelectric Point: 8.5004

>NTDB_id=61453 SCRE_RS02275 WP_020997643.1 441300..441974(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C232]
MIHFYFFLVGSIVASFLGLVVDRFPEQSIITPASHCNVCRQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGG
CLFLATSLGYLNINRLVLLAMGMTLSLYDQREQEYPLLIWLIFHIFLLFLTSFNLLMVAFLALGILTHFVDLRIGAGDFL
FLASCSTIFHLTEVLLIIQIASIIGLLLFGLKSKKDRLAFVPCLFCGGSILIMIQFIVLHQNAL

Nucleotide

• Length: 675 bp

>NTDB_id=61453 SCRE_RS02275 WP_020997643.1 441300..441974(-) (cclA/cilC) [Streptococcus constellatus subsp. pharyngis C232]
ATGATTCATTTTTATTTTTTCTTGGTTGGAAGTATTGTAGCTTCCTTTTTAGGACTGGTCGTTGATCGCTTTCCTGAGCA
GTCTATTATCACACCTGCTAGTCATTGCAACGTTTGTAGACAGAAATTAGCACCTCGTGATTTAATTCCTGTTCTTTCAC
AGCTTATCAATCGGCTGCGTTGCCGTTTTTGCAACTCAAAAATTCCCATCCGTTACATCCTTCTAGAACTAACTGGTGGC
TGTCTCTTTCTTGCAACATCTTTAGGTTATCTAAACATCAACCGGCTCGTTTTGCTTGCAATGGGAATGACCTTATCCCT
TTATGATCAAAGAGAACAAGAATATCCTCTCCTCATCTGGTTAATCTTCCATATTTTTCTCCTTTTTTTGACAAGCTTCA
ATCTTTTAATGGTTGCTTTTTTAGCACTTGGGATTTTGACTCACTTCGTTGATTTACGTATCGGTGCAGGAGACTTTCTT
TTTCTGGCATCTTGCTCAACTATTTTTCATCTGACTGAAGTTCTTCTCATTATTCAAATTGCTAGTATCATTGGTCTGCT
CCTTTTTGGTTTAAAATCAAAAAAAGACAGGTTAGCCTTTGTTCCCTGTCTTTTCTGTGGTGGCAGCATCCTGATAATGA
TACAATTTATCGTTCTTCACCAAAATGCCTTATGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-87)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus mitis SK321	58.019	94.643	0.549
cclA/cilC	Streptococcus mitis NCTC 12261	57.547	94.643	0.545
cclA/cilC	Streptococcus pneumoniae TIGR4	57.075	94.643	0.54
cclA/cilC	Streptococcus pneumoniae Rx1	56.604	94.643	0.536
cclA/cilC	Streptococcus pneumoniae D39	56.604	94.643	0.536
cclA/cilC	Streptococcus pneumoniae R6	56.604	94.643	0.536