Detailed information NTG0611355

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LE167_RS08205
• Genome accession: NZ_CP084443
• Coordinates: 1693336..1694379 (-)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1688336..1699379

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LE167_RS08175 (LE167_08200)	-	1688757..1689938 (-)	1182	WP_230454756.1	aminopeptidase	-
LE167_RS08180 (LE167_08205)	-	1690008..1690193 (-)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LE167_RS08185 (LE167_08210)	-	1690357..1690821 (+)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
LE167_RS08190 (LE167_08215)	-	1690828..1691112 (+)	285	WP_002461330.1	YtxH domain-containing protein	-
LE167_RS08195 (LE167_08220)	-	1691315..1692544 (+)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
LE167_RS08200 (LE167_08225)	vraR	1692717..1693346 (-)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LE167_RS08205 (LE167_08230)	vraS	1693336..1694379 (-)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LE167_RS08210 (LE167_08235)	liaF	1694376..1695077 (-)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LE167_RS08215 (LE167_08240)	-	1695102..1695488 (-)	387	WP_002477960.1	hypothetical protein	-
LE167_RS08220 (LE167_08245)	map	1695614..1696369 (-)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LE167_RS08225 (LE167_08250)	-	1696614..1697594 (+)	981	WP_002477959.1	FUSC family protein	-
LE167_RS08230 (LE167_08255)	-	1697728..1699089 (+)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611355 LE167_RS08205 WP_002461334.1 1693336..1694379(-) (vraS) [Staphylococcus lugdunensis strain RMLUG5]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611355 LE167_RS08205 WP_002461334.1 1693336..1694379(-) (vraS) [Staphylococcus lugdunensis strain RMLUG5]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911