Detailed information NTG0606849

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: LA346_RS07390
• Genome accession: NZ_CP083627
• Coordinates: 1411796..1412533 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain FDAARGOS_1508
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1406796..1417533

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LA346_RS07355 (LA346_07355)	-	1407726..1407965 (-)	240	WP_001810235.1	hypothetical protein	-
LA346_RS07360 (LA346_07360)	-	1408127..1408414 (-)	288	WP_000777760.1	hypothetical protein	-
LA346_RS07365 (LA346_07365)	-	1408424..1408834 (-)	411	WP_001278299.1	HIT family protein	-
LA346_RS07370 (LA346_07370)	pptA	1408902..1409633 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
LA346_RS07375 (LA346_07375)	-	1409630..1410679 (+)	1050	WP_000653767.1	ABC transporter permease	-
LA346_RS07380 (LA346_07380)	-	1410847..1411176 (-)	330	WP_000132572.1	hypothetical protein	-
LA346_RS07385 (LA346_07385)	-	1411453..1411791 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
LA346_RS07390 (LA346_07390)	comE/blpR	1411796..1412533 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
LA346_RS07395 (LA346_07395)	-	1412547..1413887 (+)	1341	WP_001017638.1	sensor histidine kinase	-
LA346_RS07400 (LA346_07400)	blpC	1413929..1414084 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
LA346_RS07405 (LA346_07405)	-	1414141..1415502 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
LA346_RS07410 (LA346_07410)	comA/nlmT	1415513..1417189 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=606849 LA346_RS07390 WP_001219120.1 1411796..1412533(+) (comE/blpR) [Streptococcus pneumoniae strain FDAARGOS_1508]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=606849 LA346_RS07390 WP_001219120.1 1411796..1412533(+) (comE/blpR) [Streptococcus pneumoniae strain FDAARGOS_1508]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363