Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   K8B76_RS05955 Genome accession   NZ_CP082820
Coordinates   1213285..1215525 (-) Length   746 a.a.
NCBI ID   WP_000942412.1    Uniprot ID   A0A6I3U6Q9
Organism   Streptococcus pneumoniae strain SCAID PHRX1-2021     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1208285..1220525
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K8B76_RS05920 (K8B76_05920) - 1209195..1209575 (-) 381 WP_000157154.1 VOC family protein -
  K8B76_RS05925 (K8B76_05925) rplT 1209633..1209992 (-) 360 WP_000124836.1 50S ribosomal protein L20 -
  K8B76_RS05930 (K8B76_05930) rpmI 1210044..1210244 (-) 201 WP_001125943.1 50S ribosomal protein L35 -
  K8B76_RS05935 (K8B76_05935) infC 1210277..1210807 (-) 531 WP_000848180.1 translation initiation factor IF-3 -
  K8B76_RS05940 (K8B76_05940) - 1211114..1212295 (-) 1182 WP_000655958.1 ABC transporter permease -
  K8B76_RS05945 (K8B76_05945) - 1212299..1212886 (-) 588 Protein_1189 ATP-binding cassette domain-containing protein -
  K8B76_RS05950 (K8B76_05950) - 1212918..1213106 (-) 189 WP_010976492.1 hypothetical protein -
  K8B76_RS05955 (K8B76_05955) comEC/celB 1213285..1215525 (-) 2241 WP_000942412.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  K8B76_RS05960 (K8B76_05960) comEA/celA/cilE 1215509..1216159 (-) 651 WP_000387335.1 helix-hairpin-helix domain-containing protein Machinery gene
  K8B76_RS05965 (K8B76_05965) - 1216227..1216796 (-) 570 WP_000443774.1 GNAT family N-acetyltransferase -
  K8B76_RS10765 ald 1216973..1218084 (+) 1112 Protein_1194 alanine dehydrogenase -
  K8B76_RS05985 (K8B76_05985) - 1218385..1218710 (-) 326 Protein_1195 TfoX/Sxy family protein -
  K8B76_RS05990 (K8B76_05990) - 1218713..1219213 (-) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  K8B76_RS06000 (K8B76_06000) - 1219406..1220374 (-) 969 WP_000658183.1 PhoH family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84643.22 Da        Isoelectric Point: 9.6207

>NTDB_id=602539 K8B76_RS05955 WP_000942412.1 1213285..1215525(-) (comEC/celB) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSTSYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFFTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFIFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVASRPLVFGQPNTWLLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIKKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPYQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=602539 K8B76_RS05955 WP_000942412.1 1213285..1215525(-) (comEC/celB) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
TTCAACATCCTATCTTGCTTTGTTGGGATTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTTACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTATCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGTAGACCGCTTGTCTTTGGACAACCCAATACATGGCTTTTAATCCTATTGTTAATTTCTTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCAAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAAGCTTGATACCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCTATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Domain of unknown function (DUF4131) (DUF4131)

(31-176)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)

Competence protein (Competence)

(216-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3U6Q9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae Rx1

98.525

100

0.985
  comEC/celB Streptococcus pneumoniae D39

98.525

100

0.985
  comEC/celB Streptococcus pneumoniae R6

98.525

100

0.985
  comEC/celB Streptococcus pneumoniae TIGR4

97.721

100

0.977
  comEC/celB Streptococcus mitis SK321

91.287

100

0.913
  comEC/celB Streptococcus mitis NCTC 12261

90.872

99.866

0.908
  comEC Lactococcus lactis subsp. cremoris KW2

44.13

99.33

0.438