Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   K8B76_RS02565 Genome accession   NZ_CP082820
Coordinates   531387..532124 (+) Length   245 a.a.
NCBI ID   WP_001219133.1    Uniprot ID   A0A6I3U4L2
Organism   Streptococcus pneumoniae strain SCAID PHRX1-2021     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 526387..537124
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K8B76_RS02535 (K8B76_02535) - 527719..528006 (-) 288 WP_084572380.1 hypothetical protein -
  K8B76_RS02540 (K8B76_02540) - 528016..528426 (-) 411 WP_001278322.1 HIT family protein -
  K8B76_RS02545 (K8B76_02545) pptA 528494..529225 (+) 732 WP_000889956.1 ABC transporter ATP-binding protein Regulator
  K8B76_RS02550 (K8B76_02550) - 529222..530271 (+) 1050 WP_000653754.1 ABC transporter permease -
  K8B76_RS02555 (K8B76_02555) - 530439..530768 (-) 330 WP_000132575.1 hypothetical protein -
  K8B76_RS02560 (K8B76_02560) - 531044..531382 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  K8B76_RS02565 (K8B76_02565) comE/blpR 531387..532124 (+) 738 WP_001219133.1 LytTR family DNA-binding domain-containing protein Regulator
  K8B76_RS02570 (K8B76_02570) - 532138..533478 (+) 1341 WP_001017640.1 sensor histidine kinase -
  K8B76_RS02575 (K8B76_02575) blpC 533549..533677 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  K8B76_RS02580 (K8B76_02580) - 533734..535095 (-) 1362 WP_001069072.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28870.07 Da        Isoelectric Point: 6.4147

>NTDB_id=602525 K8B76_RS02565 WP_001219133.1 531387..532124(+) (comE/blpR) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLNSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=602525 K8B76_RS02565 WP_001219133.1 531387..532124(+) (comE/blpR) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAATTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3U4L2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363