NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	MZN67_RS06140	Genome accession	NZ_CP096116
Coordinates	1354680..1355357 (-)	Length	225 a.a.
NCBI ID	WP_011213604.1	Uniprot ID	-
Organism	Legionella pneumophila subsp. pneumophila strain DFS-2111020037
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1349680..1360357

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MZN67_RS06115 (MZN67_06090)	-	1350994..1351737 (+)	744	WP_011213598.1	YebC/PmpR family DNA-binding transcriptional regulator	-
MZN67_RS06120 (MZN67_06095)	ruvC	1351737..1352261 (+)	525	WP_027220718.1	crossover junction endodeoxyribonuclease RuvC	-
MZN67_RS06125 (MZN67_06100)	ruvA	1352258..1352857 (+)	600	WP_011213600.1	Holliday junction branch migration protein RuvA	-
MZN67_RS06130 (MZN67_06105)	-	1352907..1353227 (+)	321	WP_027220717.1	hypothetical protein	-
MZN67_RS06135 (MZN67_06110)	-	1353268..1354683 (-)	1416	WP_010947022.1	ATP-binding protein	-
MZN67_RS06140 (MZN67_06115)	ciaR	1354680..1355357 (-)	678	WP_011213604.1	response regulator	Regulator
MZN67_RS06145 (MZN67_06120)	-	1355418..1355963 (-)	546	WP_011215337.1	septation protein A	-
MZN67_RS06150 (MZN67_06125)	-	1356207..1357646 (-)	1440	WP_027220716.1	LysM peptidoglycan-binding domain-containing protein	-
MZN67_RS06155 (MZN67_06130)	gloB	1357760..1358524 (-)	765	WP_374152280.1	hydroxyacylglutathione hydrolase	-
MZN67_RS06160 (MZN67_06135)	-	1358528..1359376 (-)	849	WP_062725072.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
MZN67_RS06165 (MZN67_06140)	-	1359664..1359873 (+)	210	WP_011213609.1	hypothetical protein	-

Sequence

Protein

Download Length: 225 a.a. Molecular weight: 25151.74 Da Isoelectric Point: 4.9981

                                >NTDB_id=585976 MZN67_RS06140 WP_011213604.1 1354680..1355357(-) (ciaR) [Legionella pneumophila subsp. pneumophila strain DFS-2111020037]

MRLLLVEDDELLGDAVKAGLTQFGYVVDWLKDGEAARAALKSESFELIILDLGLPKLSGLSLLQNIRHDGNSTPVIILTA

RESIEDRVKGLDSGADDYLIKPFDLNELSARIRALVRRSQGRADSVLQYKNITLDPAAHSVFVDDVLVNVPRREFALLQK

LLENSGQVLSREQLMQSIYGWEEDVDSNALEVHIHNLRKKLNANFIRTIRGVGYMAEKNDSVLLS

Nucleotide

Download Length: 678 bp

                                >NTDB_id=585976 MZN67_RS06140 WP_011213604.1 1354680..1355357(-) (ciaR) [Legionella pneumophila subsp. pneumophila strain DFS-2111020037]

ATGAGATTATTACTTGTTGAAGACGATGAACTGCTTGGCGATGCAGTAAAAGCCGGACTGACACAATTTGGTTATGTTGT

TGACTGGCTAAAAGATGGCGAAGCTGCTCGGGCGGCTCTCAAATCAGAGTCTTTTGAATTAATTATTCTTGACTTGGGAT

TACCTAAATTATCCGGTTTATCATTATTGCAAAACATCAGACATGATGGAAATAGCACACCTGTGATTATTCTTACAGCT

CGAGAATCAATAGAAGATCGGGTGAAAGGCTTAGATAGCGGTGCTGACGATTATCTTATTAAACCTTTTGATTTAAACGA

ATTAAGTGCAAGGATTAGAGCATTGGTAAGACGCTCTCAGGGCAGAGCTGATTCCGTGTTGCAATATAAAAATATTACCC

TCGATCCTGCTGCTCATTCTGTATTCGTGGATGATGTACTCGTCAATGTTCCAAGAAGAGAATTTGCTCTATTGCAGAAA

TTACTTGAAAACAGTGGACAGGTTTTATCTCGAGAACAATTAATGCAGAGTATTTATGGCTGGGAAGAAGACGTGGACAG

TAATGCTCTCGAAGTTCATATCCATAATTTACGTAAAAAACTTAACGCAAACTTTATCCGCACTATACGTGGTGTAGGAT

ATATGGCTGAAAAAAATGACAGTGTACTTCTATCGTGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(148-215)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae D39	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae R6	38.356	97.333	0.373
ciaR	Streptococcus pneumoniae TIGR4	38.356	97.333	0.373
ciaR	Streptococcus mutans UA159	37.9	97.333	0.369
micA	Streptococcus pneumoniae Cp1015	35.345	100	0.364

Detailed information NTG0585976