Detailed information NTG0058216

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: SPN034183_RS10805
• Genome accession: NC_021028
• Coordinates: 2004096..2004758 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649971.1
• Uniprot ID: A0A0B7MFB3
• Organism: Streptococcus pneumoniae SPN034183
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1999096..2009758

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN034183_RS10780 (SPN034183_19460)	-	1999246..1999512 (-)	267	WP_001278167.1	Veg family protein	-
SPN034183_RS10785 (SPN034183_19470)	dnaB	1999514..2000866 (-)	1353	WP_000852486.1	replicative DNA helicase	-
SPN034183_RS10790 (SPN034183_19480)	rplI	2000910..2001362 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
SPN034183_RS10795 (SPN034183_19490)	-	2001359..2003332 (-)	1974	WP_000715124.1	DHH family phosphoesterase	-
SPN034183_RS10800 (SPN034183_19500)	raiA	2003468..2004016 (-)	549	WP_000599107.1	ribosome-associated translation inhibitor RaiA	-
SPN034183_RS10805 (SPN034183_19510)	comFC/cflB	2004096..2004758 (-)	663	WP_000649971.1	ComF family protein	Machinery gene
SPN034183_RS10810 (SPN034183_19520)	comFA/cflA	2004755..2006053 (-)	1299	WP_000867612.1	DEAD/DEAH box helicase	Machinery gene
SPN034183_RS10815 (SPN034183_19530)	-	2006109..2006744 (+)	636	WP_000395739.1	YigZ family protein	-
SPN034183_RS10820 (SPN034183_19540)	cysK	2007029..2007949 (+)	921	WP_000029867.1	cysteine synthase A	-
SPN034183_RS10825 (SPN034183_19550)	-	2008188..2008553 (-)	366	Protein_2035	IS66 family transposase	-
SPN034183_RS10830 (SPN034183_19560)	-	2008535..2008822 (+)	288	Protein_2036	transposase	-
SPN034183_RS10835 (SPN034183_19570)	tnpB	2008977..2009300 (-)	324	WP_000973415.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25241.10 Da
• Isoelectric Point: 7.3688

>NTDB_id=58216 SPN034183_RS10805 WP_000649971.1 2004096..2004758(-) (comFC/cflB) [Streptococcus pneumoniae SPN034183]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=58216 SPN034183_RS10805 WP_000649971.1 2004096..2004758(-) (comFC/cflB) [Streptococcus pneumoniae SPN034183]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAACTTTGGTGTAAAGAAGGAGTTGAAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAACAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A0B7MFB3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae TIGR4	100	100	1
comFC/cflB	Streptococcus pneumoniae Rx1	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae D39	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae R6	99.545	100	0.995
comFC/cflB	Streptococcus mitis NCTC 12261	91.818	100	0.918
comFC/cflB	Streptococcus mitis SK321	91.364	100	0.914