Detailed information NTG0058106

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SPN994038_RS08545
• Genome accession: NC_021026
• Coordinates: 1603148..1603807 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565024.1
• Uniprot ID: A0A4J1XTA1
• Organism: Streptococcus pneumoniae SPN994038
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1598148..1608807

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN994038_RS08520 (SPN994038_15770)	-	1598453..1598770 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
SPN994038_RS08525 (SPN994038_15780)	-	1598785..1599681 (-)	897	WP_000825665.1	PEP phosphonomutase	-
SPN994038_RS08530 (SPN994038_15790)	-	1599684..1600946 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
SPN994038_RS08535 (SPN994038_15800)	-	1601226..1602404 (+)	1179	WP_000175878.1	ROK family transcriptional regulator	-
SPN994038_RS08540 (SPN994038_15810)	-	1602632..1603078 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
SPN994038_RS08545 (SPN994038_15820)	cclA/cilC	1603148..1603807 (+)	660	WP_000565024.1	prepilin peptidase	Machinery gene
SPN994038_RS08550 (SPN994038_15830)	-	1603859..1605010 (-)	1152	WP_000481758.1	XRE family transcriptional regulator	-
SPN994038_RS08555 (SPN994038_15840)	-	1605025..1605756 (-)	732	WP_000934017.1	hypothetical protein	-
SPN994038_RS12720	-	1605982..1606086 (+)	105	Protein_1653	prepilin peptidase	-
SPN994038_RS08560 (SPN994038_15850)	trpA	1606058..1606834 (-)	777	WP_001127028.1	tryptophan synthase subunit alpha	-
SPN994038_RS08565 (SPN994038_15860)	trpB	1606827..1608050 (-)	1224	WP_000331297.1	tryptophan synthase subunit beta	-
SPN994038_RS08570 (SPN994038_15870)	-	1608028..1608627 (-)	600	WP_000169899.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24951.16 Da
• Isoelectric Point: 8.2409

>NTDB_id=58106 SPN994038_RS08545 WP_000565024.1 1603148..1603807(+) (cclA/cilC) [Streptococcus pneumoniae SPN994038]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=58106 SPN994038_RS08545 WP_000565024.1 1603148..1603807(+) (cclA/cilC) [Streptococcus pneumoniae SPN994038]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A4J1XTA1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae D39	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae R6	95.434	100	0.954
cclA/cilC	Streptococcus mitis SK321	91.324	100	0.913
cclA/cilC	Streptococcus mitis NCTC 12261	85.388	100	0.854