Detailed information NTG0058056

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPN034156_RS08580
• Genome accession: NC_021006
• Coordinates: 1595524..1596261 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae SPN034156
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1590524..1601261

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN034156_RS12375	-	1591456..1591695 (-)	240	WP_001813906.1	hypothetical protein	-
SPN034156_RS08550 (SPN034156_15370)	-	1591857..1592144 (-)	288	WP_000777760.1	hypothetical protein	-
SPN034156_RS08555 (SPN034156_15380)	-	1592154..1592564 (-)	411	WP_001278301.1	HIT family protein	-
SPN034156_RS08560 (SPN034156_15390)	pptA	1592632..1593363 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
SPN034156_RS08565 (SPN034156_15400)	-	1593360..1594409 (+)	1050	WP_000653771.1	ABC transporter permease	-
SPN034156_RS08570 (SPN034156_15410)	-	1594577..1594906 (-)	330	WP_000132572.1	hypothetical protein	-
SPN034156_RS08575 (SPN034156_15420)	-	1595181..1595519 (+)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
SPN034156_RS08580 (SPN034156_15430)	comE/blpR	1595524..1596261 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
SPN034156_RS08585 (SPN034156_15440)	-	1596274..1597614 (+)	1341	WP_000275284.1	sensor histidine kinase	-
SPN034156_RS08590 (SPN034156_15450)	blpC	1597659..1597814 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
SPN034156_RS08595 (SPN034156_15460)	-	1597871..1599232 (-)	1362	WP_001069095.1	bacteriocin secretion accessory protein	-
SPN034156_RS11655 (SPN034156_15470)	-	1599243..1600919 (-)	1677	Protein_1601	peptide cleavage/export ABC transporter	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=58056 SPN034156_RS08580 WP_001219126.1 1595524..1596261(+) (comE/blpR) [Streptococcus pneumoniae SPN034156]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=58056 SPN034156_RS08580 WP_001219126.1 1595524..1596261(+) (comE/blpR) [Streptococcus pneumoniae SPN034156]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384