Detailed information NTG0569636

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KJP35_RS06435
• Genome accession: NZ_CP075563
• Coordinates: 1299340..1300383 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Sta2021027
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1294340..1305383

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KJP35_RS06405 (KJP35_06350)	-	1294766..1294876 (+)	111	WP_001790257.1	hypothetical protein	-
KJP35_RS06410 (KJP35_06355)	-	1294905..1295318 (+)	414	WP_001670387.1	hypothetical protein	-
KJP35_RS06415 (KJP35_06360)	-	1295749..1296735 (-)	987	WP_000999716.1	aromatic acid exporter family protein	-
KJP35_RS06420 (KJP35_06365)	map	1297266..1298024 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KJP35_RS06425 (KJP35_06370)	-	1298241..1298627 (+)	387	WP_001110179.1	hypothetical protein	-
KJP35_RS06430 (KJP35_06375)	liaF	1298642..1299343 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KJP35_RS06435 (KJP35_06380)	vraS	1299340..1300383 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KJP35_RS06440 (KJP35_06385)	vraR	1300373..1301002 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KJP35_RS06445 (KJP35_06390)	-	1301114..1302331 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
KJP35_RS06450 (KJP35_06395)	-	1302609..1302884 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KJP35_RS06455 (KJP35_06400)	-	1302891..1303355 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KJP35_RS06460 (KJP35_06405)	-	1303502..1303702 (+)	201	WP_000180460.1	DUF1128 family protein	-
KJP35_RS06465 (KJP35_06410)	-	1303705..1304961 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=569636 KJP35_RS06435 WP_001017131.1 1299340..1300383(+) (vraS) [Staphylococcus aureus strain Sta2021027]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=569636 KJP35_RS06435 WP_001017131.1 1299340..1300383(+) (vraS) [Staphylococcus aureus strain Sta2021027]
ATGAACCATTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1