Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SITYG_RS09745 Genome accession   NZ_AP014880
Coordinates   1903386..1905332 (-) Length   648 a.a.
NCBI ID   WP_021003321.1    Uniprot ID   T1ZI05
Organism   Streptococcus intermedius strain TYG1620     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1898386..1910332
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SITYG_RS09715 (SITYG_19130) cinA 1899335..1900603 (-) 1269 WP_096363248.1 competence/damage-inducible protein A Machinery gene
  SITYG_RS09720 (SITYG_19140) - 1900739..1900912 (-) 174 Protein_1875 CPBP family intramembrane glutamate endopeptidase -
  SITYG_RS09725 (SITYG_19150) - 1900917..1901471 (-) 555 WP_096363249.1 DNA-3-methyladenine glycosylase I -
  SITYG_RS09730 (SITYG_19160) ruvA 1901481..1902071 (-) 591 WP_096363250.1 Holliday junction branch migration protein RuvA Machinery gene
  SITYG_RS09735 (SITYG_19170) - 1902241..1902747 (+) 507 WP_096363251.1 helix-turn-helix domain-containing protein -
  SITYG_RS09740 (SITYG_19180) - 1902731..1903240 (+) 510 WP_162287173.1 RDD family protein -
  SITYG_RS09745 (SITYG_19190) hexB 1903386..1905332 (-) 1947 WP_021003321.1 DNA mismatch repair endonuclease MutL Machinery gene
  SITYG_RS09750 (SITYG_19200) brsR 1905574..1906014 (+) 441 WP_041823295.1 LytTR family DNA-binding domain-containing protein Regulator
  SITYG_RS09755 (SITYG_19210) - 1906011..1906469 (+) 459 WP_020999243.1 DUF3021 domain-containing protein -
  SITYG_RS09760 (SITYG_19220) hexA 1906610..1909168 (-) 2559 WP_096363253.1 DNA mismatch repair protein MutS Machinery gene
  SITYG_RS09765 (SITYG_19230) argR 1909331..1909771 (-) 441 WP_003075336.1 arginine repressor -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73421.97 Da        Isoelectric Point: 5.1595

>NTDB_id=56579 SITYG_RS09745 WP_021003321.1 1903386..1905332(-) (hexB) [Streptococcus intermedius strain TYG1620]
MSKIIELPEKLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLKSIQVIDNGEGIEHEEVPLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSCLTIETATETDQYGTLLVARGGEIECVEPTSSTVGTKIKVENLFFNTPARLKY
MKSQQAELSHIVDVMNRLSLAHPEIAFTLINDGKKMTQTVGTGNLRQAIAGVYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEYDLIPDALENLAKSTINRVSKPEQTSLPLKENRLYYDQGRTDFFVKPQVSEDRPSFEKTDQLAQQPVAPDMP
DSRTVSIKFAERQAPSYDQLDHPELDQASMERALEKLDREGISTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYRDKIGDVDDSQQQLLVPYIFEFPADDMLRLQQRMSLLEEVGIFLEEYGVNQFILREHPIWLKEEEIESGVYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCNNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=56579 SITYG_RS09745 WP_021003321.1 1903386..1905332(-) (hexB) [Streptococcus intermedius strain TYG1620]
ATGTCAAAAATTATAGAATTACCAGAAAAACTTGCCAATCAGATTGCAGCAGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAAAACTCCATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCAGGTCTCAAGA
GTATTCAAGTCATTGATAATGGCGAAGGGATTGAGCACGAGGAAGTTCCCTTAGCTTTGCGTCGGCATGCGACGAGTAAG
ATTAAGAAACAAGCCGACCTTTTTCGAATTCGGACGTTGGGTTTTCGCGGTGAGGCCCTTCCATCTATCGCTTCCGTTTC
ATGTTTGACGATTGAAACTGCAACAGAGACAGATCAATATGGTACTCTCTTGGTAGCCCGAGGTGGTGAAATTGAGTGTG
TAGAACCAACGAGCAGCACTGTCGGAACAAAAATCAAAGTCGAAAATCTCTTTTTCAATACACCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCCGAATTATCTCATATTGTAGATGTGATGAATCGTTTAAGTTTAGCCCATCCGGAGATTGCTTT
TACTCTAATAAATGACGGTAAAAAAATGACACAAACAGTAGGAACAGGGAATCTACGCCAAGCGATTGCTGGTGTTTATG
GACTGACAACGGCAAAAAAAATGATTGAGATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGCCTGCCA
GAACTAACACGAGCTAATCGTAATTATATCACGATTCTCATCAATGGTCGCTATATTAAGAATTTCTTGCTCAATCGAGC
TATCCTTGATGGCTATGGTAGTAAGCTCATGGTGGGGCGTTTTCCGATTGCAGTGATTGCTATTCAGATTGATCCTTACC
TTGCTGATGTCAATGTTCATCCCACTAAGCAAGAAGTACGGATCTCAAAAGAGCGAGAGCTTATGGTCTTGATTTCACAA
GCGATTGCTGCGAGTCTAAAAGAGTATGATTTGATTCCAGATGCTTTGGAGAATTTAGCCAAATCAACTATTAATCGAGT
AAGTAAGCCTGAACAGACTAGCCTACCACTAAAGGAGAACCGACTTTATTACGACCAAGGAAGAACCGATTTCTTTGTGA
AACCACAAGTGTCAGAAGATCGACCTTCTTTTGAGAAAACTGACCAATTAGCTCAACAACCCGTTGCTCCAGATATGCCT
GATTCCAGAACAGTCTCTATTAAATTTGCAGAAAGGCAGGCGCCTTCTTATGACCAACTGGATCATCCTGAGTTAGATCA
AGCTAGTATGGAGAGAGCTTTAGAGAAGCTAGATAGAGAAGGAATATCAACCTTTCCAGAGTTGGAGTATTTCGGTCAAA
TGCACGGAACCTATCTCTTTGCACAAGGAAATGGTGGTCTTTATATTATTGACCAGCATGCGGCTCAAGAACGGGTCAAG
TATGAATATTATAGGGACAAAATAGGAGATGTAGATGACAGTCAGCAGCAGCTTTTGGTGCCTTATATTTTTGAATTTCC
GGCAGACGATATGCTGCGACTTCAACAACGAATGTCTCTTTTGGAAGAAGTGGGTATTTTCCTAGAAGAATATGGAGTCA
ATCAATTTATTTTGCGTGAACATCCTATTTGGCTCAAAGAAGAGGAAATTGAGTCAGGTGTCTATGAAATGTGTGATATG
CTGCTTTTGACCAAGGAAGTCTCTATTAAGAAATATCGTGCAGAGCTAGCTATTATGATGAGCTGTAAACGTTCTATTAA
GGCCAATCATAGCTTAGATGACTACTCGGCACGTGATTTAATTTTCCAACTATCACAATGCAACAATCCTTATAACTGTC
CACACGGTCGACCGGTCTTGGTTAACTTTACCAAGTCGGATATGGAAAAAATGTTTCGCCGCATTCAGGAAAATCATACT
AGCCTACGAGAGTTGGGTAAGTATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZI05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.576

100

0.759

Multiple sequence alignment