Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV55_RS12980 | Genome accession | NZ_CP073904 |
| Coordinates | 2648143..2649504 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain V1950266 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602468..2651129 | 2648143..2649504 | within | 0 |
Gene organization within MGE regions
Location: 2602468..2651129
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV55_RS12730 (KFV55_12755) | ccrA | 2602468..2603814 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV55_RS12735 (KFV55_12760) | ccrB | 2603835..2605463 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV55_RS12740 (KFV55_12765) | - | 2605934..2606284 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV55_RS12745 (KFV55_12770) | - | 2606369..2606680 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV55_RS12750 (KFV55_12775) | - | 2606699..2607220 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV55_RS12755 (KFV55_12780) | - | 2607222..2607428 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV55_RS12760 (KFV55_12785) | - | 2607421..2607744 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV55_RS12765 (KFV55_12790) | - | 2607939..2609831 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV55_RS12770 (KFV55_12795) | - | 2609838..2610215 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV55_RS12775 (KFV55_12800) | - | 2610453..2610818 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV55_RS12780 (KFV55_12805) | - | 2610811..2613225 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV55_RS12785 (KFV55_12810) | - | 2613306..2613922 (+) | 617 | Protein_2484 | CadD family cadmium resistance transporter | - |
| KFV55_RS12795 (KFV55_12820) | - | 2614196..2614834 (-) | 639 | Protein_2485 | sulfite exporter TauE/SafE family protein | - |
| KFV55_RS12800 (KFV55_12825) | cstR | 2614834..2615094 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV55_RS12805 (KFV55_12830) | - | 2615230..2616294 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV55_RS12810 (KFV55_12835) | cstB | 2616327..2617661 (+) | 1335 | Protein_2488 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV55_RS12815 (KFV55_12840) | - | 2617775..2618884 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV55_RS12820 (KFV55_12845) | psm-mec | 2619239..2619307 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV55_RS12825 (KFV55_12850) | mecI | 2619392..2619763 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV55_RS12830 (KFV55_12855) | mecR1 | 2619763..2621520 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV55_RS12835 (KFV55_12860) | mecA | 2621617..2623626 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV55_RS12840 (KFV55_12865) | - | 2623672..2624100 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV55_RS12845 (KFV55_12870) | - | 2624197..2624940 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV55_RS12850 (KFV55_12875) | - | 2625737..2626126 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV55_RS12855 (KFV55_12880) | - | 2626162..2626836 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV55_RS12860 (KFV55_12885) | - | 2627281..2628537 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV55_RS12865 (KFV55_12890) | - | 2628980..2629525 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV55_RS12870 (KFV55_12895) | - | 2629543..2629752 (-) | 210 | Protein_2500 | heavy metal translocating P-type ATPase | - |
| KFV55_RS12875 (KFV55_12900) | - | 2629922..2630680 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV55_RS12880 (KFV55_12905) | - | 2630677..2630832 (-) | 156 | Protein_2502 | metal-sensing transcriptional repressor | - |
| KFV55_RS12890 (KFV55_12915) | - | 2631055..2631345 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV55_RS12895 (KFV55_12920) | - | 2631397..2632269 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV55_RS12900 (KFV55_12925) | - | 2632439..2632885 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV55_RS12905 (KFV55_12930) | - | 2632913..2633419 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV55_RS12910 (KFV55_12935) | - | 2633435..2633746 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV55_RS12915 (KFV55_12940) | - | 2633842..2634180 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV55_RS12920 (KFV55_12945) | - | 2634286..2635962 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV55_RS12925 (KFV55_12950) | - | 2636189..2637832 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV55_RS12930 (KFV55_12955) | - | 2637829..2638200 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV55_RS12935 (KFV55_12960) | - | 2638193..2639293 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV55_RS12940 (KFV55_12965) | - | 2639520..2640995 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV55_RS12945 (KFV55_12970) | - | 2641103..2641966 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV55_RS12950 (KFV55_12975) | - | 2642164..2642469 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV55_RS12955 (KFV55_12980) | - | 2643721..2645646 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV55_RS12960 (KFV55_12985) | - | 2645976..2646302 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV55_RS12965 (KFV55_12990) | - | 2646509..2646868 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV55_RS12970 (KFV55_12995) | - | 2646980..2647318 (-) | 339 | Protein_2519 | recombinase family protein | - |
| KFV55_RS12975 (KFV55_13000) | - | 2647327..2647956 (+) | 630 | Protein_2520 | hypothetical protein | - |
| KFV55_RS12980 (KFV55_13005) | ccrA | 2648143..2649504 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV55_RS12985 (KFV55_13010) | ccrB | 2649501..2651129 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=562170 KFV55_RS12980 WP_001631036.1 2648143..2649504(+) (ccrA) [Staphylococcus epidermidis strain V1950266]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=562170 KFV55_RS12980 WP_001631036.1 2648143..2649504(+) (ccrA) [Staphylococcus epidermidis strain V1950266]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |