Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SCSC_RS08940 Genome accession   NZ_AP014647
Coordinates   1807502..1809448 (-) Length   648 a.a.
NCBI ID   WP_006269779.1    Uniprot ID   -
Organism   Streptococcus constellatus subsp. constellatus strain CCUG 24889     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1802502..1814448
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCSC_RS08915 (SCSC_1837) - 1803731..1804069 (-) 339 WP_006269785.1 hypothetical protein -
  SCSC_RS08920 (SCSC_1838) - 1804383..1805237 (+) 855 WP_006269782.1 Rgg/GadR/MutR family transcriptional regulator -
  SCSC_RS08925 (SCSC_1839) - 1805398..1805811 (+) 414 WP_006269778.1 EamA family transporter -
  SCSC_RS08930 (SCSC_1840) - 1805951..1806514 (-) 564 WP_006269774.1 DNA-3-methyladenine glycosylase I -
  SCSC_RS08935 (SCSC_1841) ruvA 1806526..1807116 (-) 591 WP_006269776.1 Holliday junction branch migration protein RuvA Machinery gene
  SCSC_RS08940 (SCSC_1842) hexB 1807502..1809448 (-) 1947 WP_006269779.1 DNA mismatch repair endonuclease MutL Machinery gene
  SCSC_RS08945 (SCSC_1843) brsR 1809695..1810135 (+) 441 WP_006269783.1 LytTR family DNA-binding domain-containing protein Regulator
  SCSC_RS08950 (SCSC_1844) - 1810132..1810590 (+) 459 WP_003071509.1 DUF3021 domain-containing protein -
  SCSC_RS08955 (SCSC_1845) hexA 1810731..1813289 (-) 2559 WP_006269780.1 DNA mismatch repair protein MutS Machinery gene
  SCSC_RS08960 (SCSC_1846) argR 1813452..1813892 (-) 441 WP_003071513.1 arginine repressor -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73334.48 Da        Isoelectric Point: 5.1034

>NTDB_id=56014 SCSC_RS08940 WP_006269779.1 1807502..1809448(-) (hexB) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLKSIQVIDNGEGIEHEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATNGGTHGTRLIAQGGEIETVEPSSCPKGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDMINRLSLAHPEVAFILLNDGKELTRTAGTGNLRQAIAGIYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEQDLIPDALENLAKSTINRANKSEQTSLPLKENRLYYDKERNDFFVRPQVSESNLPFEENATFDQQHTDTDML
ASRAVSVKFAARQTPSYDQLDHPELDQSSLERALDKLDGEETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDDSQQQLLVPYIFEFPADDMLRLKQRMNLLEEVGVFLDEYGSNQFILREYPIWMKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDNDSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=56014 SCSC_RS08940 WP_006269779.1 1807502..1809448(-) (hexB) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGTCAAAAATTATAGAATTACCAGAAAATCTTGCTAATCAGATTGCGGCTGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAGAATTCCATTGATGCTGGTGCCACTCAAATTATAGTTGAGATTGAAGAAGCAGGGCTCAAGA
GTATTCAAGTCATCGATAATGGTGAAGGAATTGAGCATGAGGAGGTTTCCTTGGCTTTGCGGCGGCACGCAACAAGTAAA
ATTAAGAAGCAAGCCGACCTTTTTCGGATTCGGACTTTGGGCTTTCGTGGTGAAGCGCTTCCGTCTATTGCTTCTGTTTC
ACGCTTGACAATTGAAACTGCGACAAATGGTGGAACACATGGGACGCGTTTAATTGCTCAGGGGGGAGAAATTGAAACTG
TGGAACCAAGTAGTTGCCCTAAGGGTACCAAAATCAAAGTGGAAGACCTTTTTTTCAACACACCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCAGAACTATCTCACATTGTAGATATGATTAACCGTTTGAGCTTAGCTCATCCAGAGGTCGCTTT
TATCTTGCTCAATGATGGTAAAGAGTTGACTCGGACAGCAGGAACAGGAAATTTGCGTCAAGCAATTGCTGGTATCTATG
GATTAACAACAGCAAAAAAAATGATTGAAATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGTCTACCA
GAGTTGACGCGTGCCAATCGTAACTACATCACCATTCTCATCAATGGTCGTTACATCAAGAATTTCCTGCTCAATCGAGC
TATTCTTGATGGTTACGGTAGTAAGCTCATGGTTGGGCGATTCCCGATTGCTGTGATTGCTATCCAGATTGATCCTTACC
TTGCAGATGTTAATGTTCATCCGACCAAGCAAGAAGTGCGGATTTCCAAGGAGCGAGAACTGATGGTCTTGATTTCGCAA
GCTATTGCTGCGAGTTTAAAAGAACAGGATTTGATTCCGGATGCTTTGGAGAATTTAGCAAAATCAACTATTAACAGAGC
AAATAAGTCGGAGCAGACGAGTCTTCCGCTCAAAGAAAACCGACTCTATTATGACAAAGAGAGAAATGACTTTTTTGTTA
GACCTCAAGTATCAGAAAGCAATCTTCCTTTTGAGGAAAATGCTACATTTGATCAGCAGCATACTGATACAGATATGCTT
GCTTCCAGAGCAGTTTCTGTCAAATTTGCAGCAAGGCAAACTCCTTCTTACGATCAGCTAGATCATCCAGAACTGGATCA
ATCAAGCTTAGAAAGAGCTTTAGATAAGTTAGATGGAGAAGAAACTTCAACTTTTCCAGAACTGGAATATTTCGGGCAAA
TGCATGGCACGTACCTCTTTGCACAAGGAAATGGTGGTCTCTATATTATCGACCAGCATGCAGCGCAGGAGCGAGTCAAG
TATGAGTATTATCGGGAAAAAATCGGTGATGTGGATGACAGTCAGCAGCAACTTTTGGTTCCCTATATCTTTGAATTTCC
AGCAGACGATATGCTGCGGCTCAAGCAGCGGATGAATCTGCTGGAAGAAGTGGGAGTTTTCTTGGACGAATACGGCAGCA
ATCAGTTTATTCTGAGGGAATACCCTATCTGGATGAAGGAAGAGGAAATCGAGTCGGGTATCTATGAGATGTGTGATATG
CTGCTCCTTACCAAGGAAGTTTCTATCAAGAAATACCGAGCTGAACTAGCGATTATGATGAGTTGCAAACGCTCTATTAA
GGCCAATCATAGCTTAGATAATGATTCGGCACGTGATTTGATCTTCCAGTTATCGCAATGTGACAATCCCTACAATTGCC
CTCACGGTCGTCCAGTTTTGGTAAACTTTACCAAATCTGATATGGAAAAAATGTTCCGTCGCATTCAGGAAAACCACACC
AGCTTGCGAGAATTGGGCAAGTATTGA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-119)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.92

100

0.764

Multiple sequence alignment