Detailed information NTG0056016

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SCSC_RS08955
• Genome accession: NZ_AP014647
• Coordinates: 1810731..1813289 (-)
• Length: 852 a.a.
• NCBI ID: WP_006269780.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. constellatus strain CCUG 24889
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1805731..1818289

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCSC_RS08930 (SCSC_1840)	-	1805951..1806514 (-)	564	WP_006269774.1	DNA-3-methyladenine glycosylase I	-
SCSC_RS08935 (SCSC_1841)	ruvA	1806526..1807116 (-)	591	WP_006269776.1	Holliday junction branch migration protein RuvA	Machinery gene
SCSC_RS08940 (SCSC_1842)	hexB	1807502..1809448 (-)	1947	WP_006269779.1	DNA mismatch repair endonuclease MutL	Machinery gene
SCSC_RS08945 (SCSC_1843)	brsR	1809695..1810135 (+)	441	WP_006269783.1	LytTR family DNA-binding domain-containing protein	Regulator
SCSC_RS08950 (SCSC_1844)	-	1810132..1810590 (+)	459	WP_003071509.1	DUF3021 domain-containing protein	-
SCSC_RS08955 (SCSC_1845)	hexA	1810731..1813289 (-)	2559	WP_006269780.1	DNA mismatch repair protein MutS	Machinery gene
SCSC_RS08960 (SCSC_1846)	argR	1813452..1813892 (-)	441	WP_003071513.1	arginine repressor	-
SCSC_RS08965 (SCSC_1847)	argS	1813996..1815684 (+)	1689	WP_006269777.1	arginine--tRNA ligase	-
SCSC_RS08970 (SCSC_1849)	-	1815829..1817355 (+)	1527	WP_115342911.1	IS1182 family transposase	-
SCSC_RS08975 (SCSC_1850)	nrdI	1817431..1817886 (-)	456	WP_006269343.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 96026.50 Da
• Isoelectric Point: 4.9598

>NTDB_id=56016 SCSC_RS08955 WP_006269780.1 1810731..1813289(-) (hexA) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAINAAQILEIALTSRNKNSENPIPMAGVPYHSVQQYIDVLI
ESGYKVAIAEQVEDPKKAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDKLENLYGLAYMDLVTGEFQVTSLSDFNM
VCGEIRNLRAREVVLGYELPESEHQVLANQMNLLLSQVGTAFEDVQLLGDELSRLEHQVAGKLLEYVHQTQLRELSHLKR
VHHYEIKDFLQMDYATMASLDLTENARTGKKHGSLYWLMDETKTAMGTRLLRRWIQQPLIDKERILKRQDVVQVFLDYFF
ERSDLADSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSNVPQIKGILQGIDHPVLGQLIENLDDIPELANLIQSAISP
DAPNVITEGNIIQTGFDEILDKYRVVMRDGTSWIADIEAKERAASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIKRLQSLAQTLATIDVLQSFAAVAEKQRFVRPEFI
ERPSIEIDKGRHAVVEKVMGAQTYIPNSISMDENVNVQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVSAESAQLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANHAISQATEHSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TDLSTSLTQLENVHVATLEKDGQVTFLHKIEAGPADKSYGIHVAKIAGLPNDLLMRADQILTRLEEQANEKPSLNPSNKG
ANDSKENQVSEQISLFTETTESPILEKLRQLDIYNMTPMEVMLAVSDMKKHL

Nucleotide

• Length: 2559 bp

>NTDB_id=56016 SCSC_RS08955 WP_006269780.1 1810731..1813289(-) (hexA) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGACAAAAGAAAAACTATCTCCGGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCGGATGCTTTTTTGCTATT
TCGCATGGGAGATTTTTATGAATTATTCTATGAAGATGCGATCAATGCAGCACAGATTTTAGAAATTGCTCTGACTAGCC
GTAATAAAAATTCGGAAAATCCAATCCCGATGGCAGGAGTTCCCTACCATTCGGTGCAACAGTATATTGATGTTTTAATT
GAATCGGGCTATAAAGTAGCGATTGCAGAGCAGGTGGAAGATCCTAAAAAAGCAGTTGGTGTAGTCAAACGTGAGGTGGT
ACAAGTCATCACACCGGGGACAGTCGTTGATTCTTCAAAACCAGATAGTCAAAATAATTTCTTGGTAGCTTTAGATAAAC
TAGAAAATTTATATGGGCTGGCTTACATGGACTTGGTTACAGGTGAATTTCAGGTCACAAGTCTTAGTGACTTTAACATG
GTCTGTGGAGAAATTCGGAACTTGCGAGCGCGTGAAGTGGTCTTAGGATATGAATTACCTGAATCAGAGCACCAAGTGTT
GGCAAATCAAATGAATTTGTTATTATCACAGGTGGGAACTGCTTTTGAAGATGTTCAGCTATTAGGGGATGAATTGTCTC
GCTTAGAACATCAAGTAGCTGGAAAACTGTTAGAATATGTTCATCAGACGCAGCTGCGTGAGCTTAGTCACTTAAAGCGA
GTTCATCATTATGAAATCAAGGATTTCTTACAGATGGATTATGCAACCATGGCAAGTCTGGATTTAACAGAGAATGCACG
TACAGGAAAGAAGCACGGTAGTCTGTATTGGCTGATGGATGAGACCAAGACAGCTATGGGGACGCGACTTTTAAGAAGAT
GGATTCAGCAGCCCTTGATTGACAAAGAGCGAATCCTTAAGCGGCAGGATGTCGTGCAGGTATTTCTAGATTATTTTTTT
GAGCGCAGTGATTTAGCAGATAGTCTCAAAGGTGTGTATGACATTGAGCGTTTAGCCAGTCGTGTTTCGTTTGGAAAGAC
CAATCCGAAAGATTTATTGCAGTTGGCGGCAACATTGAGCAATGTCCCTCAGATTAAGGGAATTTTACAAGGAATTGATC
ATCCTGTTTTGGGACAGTTGATTGAAAACTTGGATGACATTCCAGAATTGGCAAACTTGATTCAGTCGGCAATTTCTCCC
GATGCTCCAAATGTTATTACTGAAGGGAATATCATTCAAACTGGTTTTGATGAAATCTTAGATAAATATCGAGTGGTTAT
GCGAGATGGTACGAGCTGGATTGCTGATATCGAAGCGAAAGAAAGGGCGGCTAGTGGGATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTCCATGTTACTAATTCACAGTTGGAGCACGTACCTAGCCACTTTTTCCGAAAAGCA
ACGTTGAAAAATTCAGAACGATTTGGTACAGAGGAATTGGCTCGTATTGAAGGCGAAATGTTGGAAGCGCGTGAAAAATC
TGCTAATTTAGAATATGAGATTTTTATGCGTATTCGTGAAGAAGCTGGCAAATATATCAAGCGTCTGCAATCCTTGGCAC
AAACTCTGGCAACGATTGATGTATTACAAAGTTTTGCAGCAGTTGCTGAAAAGCAACGCTTTGTACGCCCAGAATTTATT
GAACGTCCTTCCATTGAAATTGATAAGGGACGGCATGCGGTTGTAGAAAAGGTCATGGGTGCACAAACCTATATTCCTAA
CAGCATTTCAATGGATGAAAATGTCAACGTTCAGCTAATTACAGGTCCAAATATGAGTGGGAAGTCAACCTATATGCGTC
AATTAGCGATTATTGTTATTATGGCTCAAATGGGTTCCTATGTTTCAGCTGAGAGTGCTCAATTACCAATTTTTGATGCC
ATCTTCACTCGAATTGGTGCGGCAGATGACTTGGTATCTGGACAATCAACCTTTATGGTAGAAATGATGGAAGCAAATCA
TGCTATTTCTCAAGCAACAGAGCACTCTCTTATTCTTTTTGATGAGTTGGGAAGAGGGACAGCGACATATGATGGGATGG
CTCTTGCTCAGGCGATTATTGAATATATCCACAATCGAACAGGGGCAAAGACCCTTTTTGCCACACACTATCATGAGTTG
ACAGACTTGTCAACTAGCTTGACACAGTTAGAAAATGTTCATGTAGCAACTTTAGAAAAAGATGGGCAAGTGACCTTCCT
TCATAAGATTGAAGCTGGTCCTGCGGATAAATCTTATGGGATTCATGTGGCAAAAATTGCAGGTTTACCGAATGATTTGC
TGATGAGAGCAGACCAGATCTTAACACGATTAGAAGAACAAGCAAATGAGAAACCGTCTCTCAATCCTTCTAATAAAGGA
GCTAATGATAGTAAGGAAAATCAAGTATCTGAGCAGATATCTTTATTCACAGAAACAACTGAATCCCCTATTTTAGAAAA
ATTACGTCAGTTGGACATCTATAACATGACTCCAATGGAAGTGATGCTGGCTGTATCAGATATGAAAAAACATCTCTGA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (255-546)

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	75.939	100	0.759
mutS	Pseudomonas stutzeri strain ATCC 17587	36.806	100	0.373