Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   J7U22_RS07335 Genome accession   NZ_CP072428
Coordinates   1415297..1415986 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain S24749     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1410297..1420986
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J7U22_RS07315 (J7U22_07295) dnaI 1411104..1412006 (-) 903 WP_014607971.1 primosomal protein DnaI -
  J7U22_RS07320 (J7U22_07300) - 1412010..1413185 (-) 1176 WP_372588803.1 DnaD domain protein -
  J7U22_RS07325 (J7U22_07305) nrdR 1413182..1413661 (-) 480 WP_011680738.1 transcriptional regulator NrdR -
  J7U22_RS07330 (J7U22_07310) covS 1413783..1415300 (-) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  J7U22_RS07335 (J7U22_07315) covR 1415297..1415986 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  J7U22_RS07340 (J7U22_07320) - 1416142..1416678 (-) 537 WP_002946488.1 DUF177 domain-containing protein -
  J7U22_RS07345 (J7U22_07325) rsmG 1416975..1417688 (+) 714 WP_138496718.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  J7U22_RS07350 (J7U22_07330) - 1417758..1419122 (+) 1365 WP_372588804.1 TrkH family potassium uptake protein -
  J7U22_RS07355 (J7U22_07335) - 1419162..1419833 (+) 672 WP_002946492.1 TrkA family potassium uptake protein -
  J7U22_RS07360 - 1419850..1420020 (-) 171 Protein_1425 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=552588 J7U22_RS07335 WP_002949638.1 1415297..1415986(-) (covR) [Streptococcus thermophilus strain S24749]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=552588 J7U22_RS07335 WP_002949638.1 1415297..1415986(-) (covR) [Streptococcus thermophilus strain S24749]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTTCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAGACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441