NTDB

Overview

Name	covR	Type	Regulator
Locus tag	J7T78_RS01635	Genome accession	NZ_CP072427
Coordinates	304552..305241 (+)	Length	229 a.a.
NCBI ID	WP_002949638.1	Uniprot ID	A0A060BFD8
Organism	Streptococcus thermophilus strain S24750
Function	repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 299552..310241

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7T78_RS01610	-	300519..300689 (+)	171	Protein_277	ascorbate 6-phosphate lactonase	-
J7T78_RS01615 (J7T78_01630)	-	300706..301377 (-)	672	WP_002946492.1	TrkA family potassium uptake protein	-
J7T78_RS01620 (J7T78_01635)	-	301417..302781 (-)	1365	WP_138496717.1	TrkH family potassium uptake protein	-
J7T78_RS01625 (J7T78_01640)	rsmG	302851..303564 (-)	714	WP_138496718.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
J7T78_RS01630 (J7T78_01645)	-	303861..304397 (+)	537	WP_002946488.1	DUF177 domain-containing protein	-
J7T78_RS01635 (J7T78_01650)	covR	304552..305241 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
J7T78_RS01640 (J7T78_01655)	covS	305238..306755 (+)	1518	WP_014607970.1	HAMP domain-containing histidine kinase	Regulator
J7T78_RS01645 (J7T78_01660)	nrdR	306877..307356 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
J7T78_RS01650 (J7T78_01665)	-	307353..308528 (+)	1176	WP_011680739.1	DnaD domain protein	-
J7T78_RS01655 (J7T78_01670)	dnaI	308532..309434 (+)	903	WP_014607971.1	primosomal protein DnaI	-

Sequence

Protein

Download Length: 229 a.a. Molecular weight: 26655.77 Da Isoelectric Point: 4.7059

                                >NTDB_id=552505 J7T78_RS01635 WP_002949638.1 304552..305241(+) (covR) [Streptococcus thermophilus strain S24750]

MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT

ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE

FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide

Download Length: 690 bp

                                >NTDB_id=552505 J7T78_RS01635 WP_002949638.1 304552..305241(+) (covR) [Streptococcus thermophilus strain S24750]

ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA

CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC

TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTTCAACAAGAAAAAGATACTTATATTATGATGATGACA

GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA

AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA

CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG

TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA

TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT

CATACATTCAGACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Streptococcus salivarius strain HSISS4	96.07	100	0.961
covR	Lactococcus lactis subsp. lactis strain DGCC12653	67.544	99.563	0.672
vicR	Streptococcus mutans UA159	45.259	100	0.459
micA	Streptococcus pneumoniae Cp1015	43.913	100	0.441

Detailed information NTG0552505