Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   J5Z97_RS01820 Genome accession   NZ_CP072112
Coordinates   330104..330790 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain M08500     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 325104..335790
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J5Z97_RS01795 (J5Z97_01795) ktrB 325245..326621 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  J5Z97_RS01800 (J5Z97_01800) rsmG 326706..327419 (-) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  J5Z97_RS01805 (J5Z97_01805) - 327569..328126 (+) 558 WP_002991847.1 LemA family protein -
  J5Z97_RS01810 (J5Z97_01810) htpX 328173..329069 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  J5Z97_RS01815 (J5Z97_01815) - 329304..329837 (+) 534 WP_011054200.1 DUF177 domain-containing protein -
  J5Z97_RS01820 (J5Z97_01820) covR 330104..330790 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  J5Z97_RS01825 (J5Z97_01825) covS 330796..332298 (+) 1503 Protein_307 two-component system sensor histidine kinase CovS -
  J5Z97_RS01830 (J5Z97_01830) - 332532..333665 (+) 1134 WP_111687954.1 ISAs1-like element IS1548 family transposase -
  J5Z97_RS01835 (J5Z97_01835) nrdR 333839..334333 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  J5Z97_RS01840 (J5Z97_01840) - 334317..335492 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=550469 J5Z97_RS01820 WP_002991052.1 330104..330790(+) (covR) [Streptococcus pyogenes strain M08500]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=550469 J5Z97_RS01820 WP_002991052.1 330104..330790(+) (covR) [Streptococcus pyogenes strain M08500]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATTATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425