Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   CO544_RS11465 Genome accession   NZ_CP089036
Coordinates   2254391..2255047 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157:H7 strain 7386WT     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2249391..2260047
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO544_RS11435 (CO544_11435) dcyD 2250270..2251256 (+) 987 WP_001128225.1 D-cysteine desulfhydrase -
  CO544_RS11440 (CO544_11440) tcyL 2251271..2251939 (+) 669 WP_001158226.1 cystine ABC transporter permease -
  CO544_RS11445 (CO544_11445) tcyN 2251936..2252688 (+) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  CO544_RS11450 (CO544_11450) sdiA 2252918..2253640 (+) 723 WP_001154288.1 transcriptional regulator SdiA -
  CO544_RS11455 (CO544_11455) yecF 2253708..2253932 (-) 225 WP_000106478.1 DUF2594 family protein YecF -
  CO544_RS11460 (CO544_11460) yecU 2253919..2254095 (-) 177 WP_001302050.1 protein YecU -
  CO544_RS28000 - 2254133..2254249 (-) 117 WP_001302039.1 hypothetical protein -
  CO544_RS11465 (CO544_11465) letA 2254391..2255047 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  CO544_RS11470 (CO544_11470) uvrC 2255044..2256876 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  CO544_RS11475 (CO544_11475) pgsA 2256933..2257481 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  CO544_RS11495 (CO544_11495) - 2258473..2258754 (+) 282 WP_001303543.1 hypothetical protein -
  CO544_RS11500 (CO544_11500) - 2258775..2258969 (+) 195 WP_115801851.1 hypothetical protein -
  CO544_RS11505 (CO544_11505) - 2258911..2259078 (+) 168 Protein_2258 hypothetical protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=547952 CO544_RS11465 WP_000611328.1 2254391..2255047(+) (letA) [Escherichia coli O157:H7 strain 7386WT]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=547952 CO544_RS11465 WP_000611328.1 2254391..2255047(+) (letA) [Escherichia coli O157:H7 strain 7386WT]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482