Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   GGS_RS00280 Genome accession   NC_018712
Coordinates   50292..51203 (+) Length   303 a.a.
NCBI ID   WP_015016522.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis RE378     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 51489..52622 50292..51203 flank 286


Gene organization within MGE regions


Location: 50292..52622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GGS_RS00280 (GGS_0053) comR 50292..51203 (+) 912 WP_015016522.1 XRE family transcriptional regulator Regulator
  GGS_RS11055 comS 51290..51385 (+) 96 WP_198455558.1 quorum-sensing system DWW-type pheromone Regulator
  GGS_RS00285 (GGS_0054) - 51489..52622 (+) 1134 WP_042357804.1 ISAs1-like element IS1548 family transposase -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35741.28 Da        Isoelectric Point: 4.5798

>NTDB_id=53933 GGS_RS00280 WP_015016522.1 50292..51203(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis RE378]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEQLIIECLQATLDTLLSENINFGVELLQEYFKQTKVKQRFKQND
LILIELYLAYLDIEGMYGEYSDKVFYDSLLDNLLKQFDDFELDELFIVNKIIIDISSLSIKTNKLDNLEKTIAISQKIMA
KIQDWNRMPILKLIEWKYFLIKQKNRKQAEESYTKACLFAQITGDKYLEEQLIKEWEKDICAY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=53933 GGS_RS00280 WP_015016522.1 50292..51203(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis RE378]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAACAATTGATTATAGAATGTTTACAGGCTACGCTAGACACTTTATTAAGTG
AAAACATCAATTTTGGTGTCGAATTATTGCAGGAATATTTTAAACAAACCAAAGTTAAACAACGTTTTAAACAAAACGAC
TTGATACTTATTGAACTCTATCTGGCTTATCTCGATATTGAAGGGATGTATGGAGAATATTCTGATAAGGTTTTTTATGA
TTCTTTGTTAGATAACCTGTTAAAACAATTCGATGACTTTGAATTAGACGAACTGTTCATAGTTAATAAAATTATTATTG
ATATTTCTTCTTTAAGTATTAAAACTAATAAACTAGATAATCTAGAAAAGACGATTGCTATAAGTCAAAAAATCATGGCA
AAAATCCAGGATTGGAATAGAATGCCTATACTAAAATTAATAGAATGGAAGTACTTTTTAATAAAACAAAAGAACAGAAA
ACAAGCAGAGGAATCATATACAAAGGCGTGTCTGTTTGCGCAAATAACAGGAGACAAGTATTTGGAAGAGCAATTAATCA
AAGAATGGGAGAAAGATATTTGTGCTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

82.178

100

0.822
  comR Streptococcus pyogenes MGAS315

54.667

99.01

0.541
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

50.847

97.36

0.495
  comR Streptococcus mutans UA159

49.498

98.68

0.488

Multiple sequence alignment