Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | I6J38_RS00225 | Genome accession | NZ_CP069558 |
| Coordinates | 43318..43992 (-) | Length | 224 a.a. |
| NCBI ID | WP_020997643.1 | Uniprot ID | - |
| Organism | Streptococcus constellatus strain FDAARGOS_1208 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 17652..50763 | 43318..43992 | within | 0 |
Gene organization within MGE regions
Location: 17652..50763
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J38_RS00095 (I6J38_00095) | - | 18090..18866 (-) | 777 | WP_006267458.1 | aminoglycoside 3'-phosphotransferase | - |
| I6J38_RS00100 (I6J38_00100) | rlmD | 18923..20287 (+) | 1365 | WP_006267121.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| I6J38_RS00105 (I6J38_00105) | - | 21145..22077 (-) | 933 | WP_006267664.1 | nitronate monooxygenase | - |
| I6J38_RS00110 (I6J38_00110) | - | 22412..22645 (+) | 234 | WP_003070208.1 | DUF1858 domain-containing protein | - |
| I6J38_RS00115 (I6J38_00115) | - | 22645..24006 (+) | 1362 | WP_006267202.1 | DUF438 domain-containing protein | - |
| I6J38_RS00120 (I6J38_00120) | - | 24019..24273 (+) | 255 | WP_006267273.1 | DUF1912 family protein | - |
| I6J38_RS00125 (I6J38_00125) | - | 24660..25238 (+) | 579 | WP_003070202.1 | GNAT family N-acetyltransferase | - |
| I6J38_RS00130 (I6J38_00130) | - | 25235..26173 (+) | 939 | WP_003070201.1 | hypothetical protein | - |
| I6J38_RS00135 (I6J38_00135) | - | 26195..28843 (+) | 2649 | WP_006267276.1 | valine--tRNA ligase | - |
| I6J38_RS00140 (I6J38_00140) | - | 28851..29240 (+) | 390 | WP_006267502.1 | hypothetical protein | - |
| I6J38_RS10270 (I6J38_00150) | - | 30734..32041 (-) | 1308 | WP_204116059.1 | albumin-binding GA domain-containing protein | - |
| I6J38_RS00155 (I6J38_00155) | - | 32180..33060 (-) | 881 | Protein_30 | ISAs1 family transposase | - |
| I6J38_RS00160 (I6J38_00160) | - | 33237..33506 (-) | 270 | Protein_31 | IS30 family transposase | - |
| I6J38_RS00165 (I6J38_00165) | - | 33611..34335 (-) | 725 | Protein_32 | ISL3 family transposase | - |
| I6J38_RS00170 (I6J38_00170) | cysK | 34289..35218 (-) | 930 | WP_020997639.1 | cysteine synthase A | - |
| I6J38_RS00175 (I6J38_00175) | - | 35317..35952 (-) | 636 | WP_003035211.1 | YigZ family protein | - |
| I6J38_RS00180 (I6J38_00180) | comFA/cflA | 36009..37310 (+) | 1302 | WP_020997640.1 | DEAD/DEAH box helicase | Machinery gene |
| I6J38_RS00185 (I6J38_00185) | - | 37307..37972 (+) | 666 | WP_006267632.1 | ComF family protein | - |
| I6J38_RS00190 (I6J38_00190) | hpf | 38051..38593 (+) | 543 | WP_006267638.1 | ribosome hibernation-promoting factor, HPF/YfiA family | - |
| I6J38_RS00195 (I6J38_00195) | rsmD | 38790..39329 (+) | 540 | WP_037592514.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| I6J38_RS00200 (I6J38_00200) | coaD | 39319..39816 (+) | 498 | WP_006267255.1 | pantetheine-phosphate adenylyltransferase | - |
| I6J38_RS00205 (I6J38_00205) | sepM | 39797..40852 (+) | 1056 | WP_020997642.1 | SepM family pheromone-processing serine protease | Regulator |
| I6J38_RS00210 (I6J38_00210) | - | 41139..41696 (+) | 558 | WP_006267391.1 | YutD family protein | - |
| I6J38_RS00215 (I6J38_00215) | rlmN | 41730..42812 (+) | 1083 | WP_006267478.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| I6J38_RS00220 (I6J38_00220) | - | 42805..43323 (+) | 519 | WP_003070167.1 | VanZ family protein | - |
| I6J38_RS00225 (I6J38_00225) | cclA/cilC | 43318..43992 (-) | 675 | WP_020997643.1 | prepilin peptidase | Machinery gene |
| I6J38_RS00230 (I6J38_00230) | - | 44143..44670 (+) | 528 | WP_006267546.1 | Dps family protein | - |
| I6J38_RS00235 (I6J38_00235) | - | 44887..46077 (-) | 1191 | WP_006267506.1 | site-specific integrase | - |
| I6J38_RS00240 (I6J38_00240) | - | 46153..46356 (-) | 204 | WP_002983016.1 | excisionase | - |
| I6J38_RS00245 (I6J38_00245) | - | 46786..47037 (-) | 252 | WP_006267285.1 | helix-turn-helix domain-containing protein | - |
| I6J38_RS00250 (I6J38_00250) | - | 47018..47461 (-) | 444 | WP_006267609.1 | RNA polymerase sigma factor | - |
| I6J38_RS00255 (I6J38_00255) | - | 47802..49136 (-) | 1335 | WP_006267371.1 | MATE family efflux transporter | - |
| I6J38_RS00260 (I6J38_00260) | - | 49770..50094 (+) | 325 | Protein_51 | plasmid mobilization protein | - |
| I6J38_RS10015 | - | 50061..50291 (+) | 231 | Protein_52 | relaxase/mobilization nuclease domain-containing protein | - |
| I6J38_RS00265 (I6J38_00265) | - | 50263..50415 (+) | 153 | WP_080654533.1 | helix-turn-helix domain-containing protein | - |
Sequence
Protein
Download Length: 224 a.a. Molecular weight: 25312.66 Da Isoelectric Point: 8.5004
>NTDB_id=535499 I6J38_RS00225 WP_020997643.1 43318..43992(-) (cclA/cilC) [Streptococcus constellatus strain FDAARGOS_1208]
MIHFYFFLVGSIVASFLGLVVDRFPEQSIITPASHCNVCRQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGG
CLFLATSLGYLNINRLVLLAMGMTLSLYDQREQEYPLLIWLIFHIFLLFLTSFNLLMVAFLALGILTHFVDLRIGAGDFL
FLASCSTIFHLTEVLLIIQIASIIGLLLFGLKSKKDRLAFVPCLFCGGSILIMIQFIVLHQNAL
MIHFYFFLVGSIVASFLGLVVDRFPEQSIITPASHCNVCRQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGG
CLFLATSLGYLNINRLVLLAMGMTLSLYDQREQEYPLLIWLIFHIFLLFLTSFNLLMVAFLALGILTHFVDLRIGAGDFL
FLASCSTIFHLTEVLLIIQIASIIGLLLFGLKSKKDRLAFVPCLFCGGSILIMIQFIVLHQNAL
Nucleotide
Download Length: 675 bp
>NTDB_id=535499 I6J38_RS00225 WP_020997643.1 43318..43992(-) (cclA/cilC) [Streptococcus constellatus strain FDAARGOS_1208]
ATGATTCATTTTTATTTTTTCTTGGTTGGAAGTATTGTAGCTTCCTTTTTAGGACTGGTCGTTGATCGCTTTCCTGAGCA
GTCTATTATCACACCTGCTAGTCATTGCAACGTTTGTAGACAGAAATTAGCACCTCGTGATTTAATTCCTGTTCTTTCAC
AGCTTATCAATCGGCTGCGTTGCCGTTTTTGCAACTCAAAAATTCCCATCCGTTACATCCTTCTAGAACTAACTGGTGGC
TGTCTCTTTCTTGCAACATCTTTAGGTTATCTAAACATCAACCGGCTCGTTTTGCTTGCAATGGGAATGACCTTATCCCT
TTATGATCAAAGAGAACAAGAATATCCTCTCCTCATCTGGTTAATCTTCCATATTTTTCTCCTTTTTTTGACAAGCTTCA
ATCTTTTAATGGTTGCTTTTTTAGCACTTGGGATTTTGACTCACTTCGTTGATTTACGTATCGGTGCAGGAGACTTTCTT
TTTCTGGCATCTTGCTCAACTATTTTTCATCTGACTGAAGTTCTTCTCATTATTCAAATTGCTAGTATCATTGGTCTGCT
CCTTTTTGGTTTAAAATCAAAAAAAGACAGGTTAGCCTTTGTTCCCTGTCTTTTCTGTGGTGGCAGCATCCTGATAATGA
TACAATTTATCGTTCTTCACCAAAATGCCTTATGA
ATGATTCATTTTTATTTTTTCTTGGTTGGAAGTATTGTAGCTTCCTTTTTAGGACTGGTCGTTGATCGCTTTCCTGAGCA
GTCTATTATCACACCTGCTAGTCATTGCAACGTTTGTAGACAGAAATTAGCACCTCGTGATTTAATTCCTGTTCTTTCAC
AGCTTATCAATCGGCTGCGTTGCCGTTTTTGCAACTCAAAAATTCCCATCCGTTACATCCTTCTAGAACTAACTGGTGGC
TGTCTCTTTCTTGCAACATCTTTAGGTTATCTAAACATCAACCGGCTCGTTTTGCTTGCAATGGGAATGACCTTATCCCT
TTATGATCAAAGAGAACAAGAATATCCTCTCCTCATCTGGTTAATCTTCCATATTTTTCTCCTTTTTTTGACAAGCTTCA
ATCTTTTAATGGTTGCTTTTTTAGCACTTGGGATTTTGACTCACTTCGTTGATTTACGTATCGGTGCAGGAGACTTTCTT
TTTCTGGCATCTTGCTCAACTATTTTTCATCTGACTGAAGTTCTTCTCATTATTCAAATTGCTAGTATCATTGGTCTGCT
CCTTTTTGGTTTAAAATCAAAAAAAGACAGGTTAGCCTTTGTTCCCTGTCTTTTCTGTGGTGGCAGCATCCTGATAATGA
TACAATTTATCGTTCTTCACCAAAATGCCTTATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus mitis SK321 |
58.019 |
94.643 |
0.549 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
57.547 |
94.643 |
0.545 |
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
57.075 |
94.643 |
0.54 |
| cclA/cilC | Streptococcus pneumoniae Rx1 |
56.604 |
94.643 |
0.536 |
| cclA/cilC | Streptococcus pneumoniae D39 |
56.604 |
94.643 |
0.536 |
| cclA/cilC | Streptococcus pneumoniae R6 |
56.604 |
94.643 |
0.536 |