Detailed information NTG0053356

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: HMPREF1038_RS08735
• Genome accession: NC_018630
• Coordinates: 1639208..1639867 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565003.1
• Uniprot ID: A0A0E9GWM6
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1634208..1644867

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS08715 (HMPREF1038_01777)	-	1634845..1635741 (-)	897	WP_001844954.1	hypothetical protein	-
HMPREF1038_RS08720 (HMPREF1038_01778)	-	1635744..1637006 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
HMPREF1038_RS08725 (HMPREF1038_01779)	-	1637286..1638464 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
HMPREF1038_RS08730 (HMPREF1038_01780)	-	1638692..1639138 (-)	447	WP_000155414.1	GNAT family N-acetyltransferase	-
HMPREF1038_RS08735 (HMPREF1038_01781)	cclA/cilC	1639208..1639867 (+)	660	WP_000565003.1	A24 family peptidase	Machinery gene
HMPREF1038_RS08740 (HMPREF1038_01782)	-	1639919..1641070 (-)	1152	WP_000481750.1	ImmA/IrrE family metallo-endopeptidase	-
HMPREF1038_RS08745 (HMPREF1038_01783)	-	1641085..1641816 (-)	732	Protein_1669	hypothetical protein	-
HMPREF1038_RS11990	-	1642036..1642146 (+)	111	Protein_1670	prepilin peptidase	-
HMPREF1038_RS08750 (HMPREF1038_01785)	trpA	1642118..1642894 (-)	777	WP_001126994.1	tryptophan synthase subunit alpha	-
HMPREF1038_RS08755 (HMPREF1038_01786)	trpB	1642887..1644110 (-)	1224	WP_000331296.1	tryptophan synthase subunit beta	-
HMPREF1038_RS08760 (HMPREF1038_01787)	-	1644088..1644687 (-)	600	WP_000169893.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24841.94 Da
• Isoelectric Point: 7.6166

>NTDB_id=53356 HMPREF1038_RS08735 WP_000565003.1 1639208..1639867(+) (cclA/cilC) [Streptococcus pneumoniae gamPNI0373]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLSIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSITELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=53356 HMPREF1038_RS08735 WP_000565003.1 1639208..1639867(+) (cclA/cilC) [Streptococcus pneumoniae gamPNI0373]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGAGCAT
CTATGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCATAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
AGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E9GWM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	86.758	100	0.868