NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	JK368_RS17980	Genome accession	NZ_CP068394
Coordinates	3737435..3738559 (-)	Length	374 a.a.
NCBI ID	WP_000228517.1	Uniprot ID	E2QFE2
Organism	Escherichia coli strain M-17
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 3732435..3743559

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JK368_RS17950 (JK368_17950)	yrdA	3734235..3734789 (+)	555	WP_001286216.1	gamma carbonic anhydrase family protein	-
JK368_RS17955 (JK368_17955)	yrdB	3734765..3735022 (-)	258	WP_001070567.1	DUF1488 domain-containing protein	-
JK368_RS17960 (JK368_17960)	aroE	3735019..3735837 (-)	819	WP_001520218.1	shikimate dehydrogenase	-
JK368_RS17965 (JK368_17965)	tsaC	3735842..3736414 (-)	573	WP_001297709.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
JK368_RS17970 (JK368_17970)	yrdD	3736419..3736961 (-)	543	WP_001312137.1	type I DNA topoisomerase	-
JK368_RS17975 (JK368_17975)	smg	3736990..3737463 (-)	474	WP_000460672.1	DUF494 family protein Smg	-
JK368_RS17980 (JK368_17980)	dprA	3737435..3738559 (-)	1125	WP_000228517.1	DNA-protecting protein DprA	Machinery gene
JK368_RS17985 (JK368_17985)	def	3738689..3739198 (+)	510	WP_000114984.1	peptide deformylase	-
JK368_RS17990 (JK368_17990)	fmt	3739213..3740160 (+)	948	WP_000004421.1	methionyl-tRNA formyltransferase	-
JK368_RS17995 (JK368_17995)	rsmB	3740212..3741501 (+)	1290	WP_000744767.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
JK368_RS18000 (JK368_18000)	trkA	3741523..3742899 (+)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
JK368_RS18005 (JK368_18005)	mscL	3743029..3743442 (+)	414	WP_000022450.1	large-conductance mechanosensitive channel protein MscL	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40910.86 Da Isoelectric Point: 6.0395

                                >NTDB_id=528961 JK368_RS17980 WP_000228517.1 3737435..3738559(-) (dprA) [Escherichia coli strain M-17]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHAPLAASLLEQGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQEDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=528961 JK368_RS17980 WP_000228517.1 3737435..3738559(-) (dprA) [Escherichia coli strain M-17]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGCATCAGCAGCTTGTATGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCATATTGATGCGGTTGTATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGCGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGTTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGATTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTTAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCTCCACTGGCTGCCAGTCTACT

TGAGCAAGGTGGTGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAAGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCTTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGGAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterproScan.

DprA winged helix domain (DprA_WH)

(312-357)

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	E2QFE2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.78	98.663	0.481
dprA	Vibrio cholerae strain A1552	49.355	82.888	0.409
dprA	Glaesserella parasuis strain SC1401	44.807	90.107	0.404
dprA	Haemophilus influenzae Rd KW20	44.214	90.107	0.398
dprA	Legionella pneumophila strain ERS1305867	44.242	88.235	0.39

Detailed information NTG0528961