Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   I6J15_RS04180 Genome accession   NZ_CP068056
Coordinates   808386..809219 (+) Length   277 a.a.
NCBI ID   WP_111713004.1    Uniprot ID   -
Organism   Streptococcus lutetiensis strain FDAARGOS_1158     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 795613..810369 808386..809219 within 0


Gene organization within MGE regions


Location: 795613..810369
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J15_RS04120 (I6J15_04120) - 795613..796326 (+) 714 WP_013852281.1 metal ABC transporter ATP-binding protein -
  I6J15_RS04125 (I6J15_04125) - 796337..797155 (+) 819 WP_230318133.1 metal ABC transporter permease -
  I6J15_RS04130 (I6J15_04130) - 797463..798568 (+) 1106 Protein_750 IS3 family transposase -
  I6J15_RS09040 - 798688..799191 (-) 504 WP_233422878.1 CPBP family intramembrane glutamic endopeptidase -
  I6J15_RS04140 (I6J15_04140) - 800050..801018 (-) 969 WP_111713006.1 L-lactate dehydrogenase -
  I6J15_RS09045 - 801497..801823 (+) 327 WP_041973728.1 hypothetical protein -
  I6J15_RS09050 - 801827..803071 (+) 1245 WP_231844747.1 Cna B-type domain-containing protein -
  I6J15_RS09055 - 803068..803751 (+) 684 WP_231872449.1 SpaA isopeptide-forming pilin-related protein -
  I6J15_RS09060 - 803754..803831 (+) 78 Protein_756 hypothetical protein -
  I6J15_RS04150 (I6J15_04150) - 803968..804738 (+) 771 WP_003066600.1 TatD family hydrolase -
  I6J15_RS04155 (I6J15_04155) rnmV 804731..805300 (+) 570 WP_167394768.1 ribonuclease M5 -
  I6J15_RS04160 (I6J15_04160) rsmA 805423..806295 (+) 873 WP_021143191.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
  I6J15_RS04165 (I6J15_04165) - 806702..806851 (+) 150 WP_020917491.1 hypothetical protein -
  I6J15_RS04170 (I6J15_04170) - 806864..807169 (+) 306 WP_020917490.1 bacteriocin immunity protein -
  I6J15_RS04175 (I6J15_04175) - 807197..807490 (+) 294 WP_020917489.1 bacteriocin immunity protein -
  I6J15_RS04180 (I6J15_04180) comD/comD2 808386..809219 (+) 834 WP_111713004.1 sensor histidine kinase Regulator
  I6J15_RS09065 comE/comE2 809777..810004 (+) 228 WP_233422877.1 hypothetical protein Regulator
  I6J15_RS09070 comE/comE2 809989..810369 (+) 381 WP_267895290.1 LytR/AlgR family response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 277 a.a.        Molecular weight: 31707.21 Da        Isoelectric Point: 4.6102

>NTDB_id=526680 I6J15_RS04180 WP_111713004.1 808386..809219(+) (comD/comD2) [Streptococcus lutetiensis strain FDAARGOS_1158]
MVSYFLFMDAVAIVKPFHNTVNDAIRGIVAFIYLILLFVFLFYLNFRHGQEQKNELLRNQEMELAALENCSKHVESLYQE
VRSFRHDYANVLMSLKVGIDQGNLDDIKKIYNEITANSTKLVKNNKFDLTRLANIIDSGVKSFMSAKFLQAENQGIAISL
EVAEKMENPSMPLIYYIRILSILFDNAIEAALESETPEISVANFYQDGNFVFMIENSTKEKSVDLTKIFERGYSTKGENR
GLGLATLMDFQDDDENLSVEIRSSDYTFTQVVRIFDA

Nucleotide


Download         Length: 834 bp        

>NTDB_id=526680 I6J15_RS04180 WP_111713004.1 808386..809219(+) (comD/comD2) [Streptococcus lutetiensis strain FDAARGOS_1158]
ATGGTCTCTTATTTTTTATTCATGGATGCCGTTGCTATTGTAAAACCTTTTCATAATACTGTTAACGATGCAATAAGGGG
AATTGTTGCTTTCATTTATCTCATCCTTCTTTTTGTCTTCCTCTTTTATCTTAATTTCCGTCATGGGCAAGAGCAGAAAA
ATGAATTGCTTCGTAACCAGGAAATGGAATTGGCGGCCTTGGAAAATTGTAGCAAGCACGTGGAGAGTTTGTATCAGGAG
GTTCGCAGTTTCAGGCATGACTACGCTAATGTCCTGATGAGTTTAAAGGTTGGAATTGATCAAGGCAATCTTGATGACAT
CAAGAAAATTTACAACGAAATCACAGCCAATTCGACGAAGCTAGTCAAGAATAATAAATTTGACCTGACTCGCTTGGCTA
ACATCATAGACAGCGGCGTCAAAAGCTTCATGTCAGCTAAATTTTTGCAAGCTGAAAATCAAGGGATTGCAATTAGTCTA
GAAGTCGCCGAAAAAATGGAAAATCCTAGCATGCCATTAATTTATTACATTCGAATTTTGTCGATTCTGTTTGATAATGC
CATAGAAGCCGCTTTGGAGTCAGAAACTCCAGAAATCTCAGTCGCTAATTTTTACCAAGATGGTAACTTTGTTTTCATGA
TTGAGAATTCAACTAAGGAAAAATCAGTGGATTTAACTAAGATTTTTGAGCGTGGCTACTCAACTAAGGGAGAAAATCGT
GGACTTGGTCTAGCCACACTAATGGATTTCCAAGATGACGACGAAAATCTGTCAGTTGAAATTCGCAGCTCAGATTACAC
ATTTACACAAGTTGTCCGAATTTTTGATGCATAA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(177-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus equinus JB1

88.087

100

0.881
  comD/comD3 Streptococcus equinus JB1

83.026

97.834

0.812
  comD/blpH Streptococcus mutans UA159

39.051

98.917

0.386
  comD/comD1 Streptococcus equinus JB1

46.32

83.394

0.386