Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   JF649_RS01550 Genome accession   NZ_CP066541
Coordinates   295059..295745 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS270     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 290059..300745
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JF649_RS01525 (JF649_01535) ktrB 290201..291577 (-) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -
  JF649_RS01530 (JF649_01540) rsmG 291662..292375 (-) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  JF649_RS01535 (JF649_01545) - 292525..293082 (+) 558 WP_002985956.1 LemA family protein -
  JF649_RS01540 (JF649_01550) htpX 293129..294025 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  JF649_RS01545 (JF649_01555) - 294259..294792 (+) 534 WP_011054200.1 DUF177 domain-containing protein -
  JF649_RS01550 (JF649_01560) covR 295059..295745 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  JF649_RS01555 (JF649_01565) covS 295751..297253 (+) 1503 WP_136047585.1 two-component system sensor histidine kinase CovS -
  JF649_RS01560 (JF649_01570) - 297487..298620 (+) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  JF649_RS01570 (JF649_01575) nrdR 298794..299288 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  JF649_RS01575 (JF649_01580) - 299272..300447 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=520681 JF649_RS01550 WP_002991052.1 295059..295745(+) (covR) [Streptococcus pyogenes strain MGAS270]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=520681 JF649_RS01550 WP_002991052.1 295059..295745(+) (covR) [Streptococcus pyogenes strain MGAS270]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425