Detailed information NTG0517083

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: I6H74_RS01315
• Genome accession: NZ_CP066069
• Coordinates: 249075..249986 (-)
• Length: 303 a.a.
• NCBI ID: WP_115256701.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae strain FDAARGOS_1017
• Function: activate transcription of comX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	249075..261464	249075..249986	within	0

Gene organization within MGE regions

Location: 249075..261464

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H74_RS01315 (I6H74_01310)	comR	249075..249986 (-)	912	WP_115256701.1	XRE family transcriptional regulator	Regulator
I6H74_RS01320 (I6H74_01315)	purB	250128..251420 (-)	1293	WP_022554088.1	adenylosuccinate lyase	-
I6H74_RS01325 (I6H74_01320)	-	251605..253464 (-)	1860	WP_015016520.1	DUF262 domain-containing protein	-
I6H74_RS01330 (I6H74_01325)	purK	253483..254556 (-)	1074	WP_115256700.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6H74_RS01335 (I6H74_01330)	purE	254543..255031 (-)	489	WP_046177508.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6H74_RS01340 (I6H74_01335)	-	255462..256325 (+)	864	WP_046177583.1	IS982 family transposase	-
I6H74_RS01345 (I6H74_01340)	purD	256636..257898 (-)	1263	WP_046177522.1	phosphoribosylamine--glycine ligase	-
I6H74_RS01350 (I6H74_01345)	-	258182..259309 (+)	1128	WP_003055557.1	SH3 domain-containing protein	-
I6H74_RS01355 (I6H74_01350)	purH	259389..260933 (-)	1545	WP_046177523.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
I6H74_RS01360 (I6H74_01355)	-	260952..261464 (-)	513	WP_015057184.1	VanZ family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35712.29 Da
• Isoelectric Point: 4.5798

>NTDB_id=517083 I6H74_RS01315 WP_115256701.1 249075..249986(-) (comR) [Streptococcus dysgalactiae strain FDAARGOS_1017]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEQLIIECLQATLDTLLSENINFGVELLQEYFKQTKVKLRFKQND
LILIELYLAYLDIEGMYGEYSDKVFYDSLLDNLLKQFDDFELDELFIVNKVIIDISSLSIKTNKLDNLEKTIAISQKIMA
KIQDWNRMPILKLIEWKYFLIKQKNRKQAEESYTKACLFAQITGDKYLEEQLIKEWEKDICAY

Nucleotide

• Length: 912 bp

>NTDB_id=517083 I6H74_RS01315 WP_115256701.1 249075..249986(-) (comR) [Streptococcus dysgalactiae strain FDAARGOS_1017]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGTGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAACAATTGATTATAGAATGTTTACAGGCTACGCTAGACACTTTATTAAGTG
AAAACATCAATTTTGGTGTCGAATTATTGCAGGAATATTTTAAACAAACCAAAGTTAAACTACGTTTTAAACAAAACGAC
TTGATACTTATTGAACTCTATCTGGCTTATCTCGATATTGAAGGGATGTATGGAGAATATTCTGATAAGGTTTTTTATGA
TTCTTTGTTAGATAACCTGTTAAAACAATTCGATGACTTTGAATTAGACGAACTGTTCATAGTTAATAAAGTTATTATTG
ATATTTCTTCTTTAAGTATTAAAACTAATAAACTAGATAATCTAGAAAAGACGATTGCTATAAGTCAAAAAATCATGGCA
AAAATCCAGGATTGGAATAGAATGCCTATACTAAAATTAATAGAATGGAAGTACTTTTTAATAAAACAAAAGAACAGAAA
ACAAGCAGAGGAATCATATACAAAGGCGTGTCTGTTTGCGCAAATAACAGGAGACAAGTATTTGGAAGAGCAATTAATCA
AAGAATGGGAGAAAGATATTTGTGCTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	81.848	100	0.818
comR	Streptococcus pyogenes MGAS315	54.333	99.01	0.538
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.186	97.36	0.498
comR	Streptococcus mutans UA159	49.833	98.68	0.492