Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   KW2_RS11275 Genome accession   NC_022369
Coordinates   2341575..2343545 (-) Length   656 a.a.
NCBI ID   WP_021037999.1    Uniprot ID   -
Organism   Lactococcus cremoris subsp. cremoris KW2     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2336575..2348545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KW2_RS11245 (kw2_2265) - 2337071..2337271 (+) 201 WP_011836112.1 hypothetical protein -
  KW2_RS11250 (kw2_2266) glnA 2337332..2338672 (-) 1341 WP_021037996.1 type I glutamate--ammonia ligase -
  KW2_RS11255 (kw2_2267) - 2338734..2339099 (-) 366 WP_011836114.1 MerR family transcriptional regulator -
  KW2_RS11260 (kw2_2268) - 2339200..2339637 (-) 438 WP_021037997.1 low molecular weight protein-tyrosine-phosphatase -
  KW2_RS11265 (kw2_2269) ruvB 2339782..2340783 (-) 1002 WP_014573419.1 Holliday junction branch migration DNA helicase RuvB Machinery gene
  KW2_RS11270 (kw2_2270) ruvA 2340930..2341523 (-) 594 WP_021037998.1 Holliday junction branch migration protein RuvA Machinery gene
  KW2_RS11275 (kw2_2271) hexB 2341575..2343545 (-) 1971 WP_021037999.1 DNA mismatch repair endonuclease MutL Machinery gene
  KW2_RS11280 (kw2_2272) - 2343675..2344370 (-) 696 WP_021038000.1 hypothetical protein -
  KW2_RS11285 (kw2_2273) hexA 2344480..2347002 (-) 2523 WP_021038001.1 DNA mismatch repair protein MutS Machinery gene
  KW2_RS11290 (kw2_2274) - 2347118..2347465 (-) 348 WP_021038002.1 RicAFT regulatory complex protein RicA family protein -
  KW2_RS11295 (kw2_2275) - 2347631..2348512 (-) 882 WP_021038003.1 NAD(P)-dependent oxidoreductase -

Sequence

Protein


Download         Length: 656 a.a.        Molecular weight: 73721.95 Da        Isoelectric Point: 5.5027

>NTDB_id=51701 KW2_RS11275 WP_021037999.1 2341575..2343545(-) (hexB) [Lactococcus cremoris subsp. cremoris KW2]
MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVTDNGLGLEKEDVALALRRHATSK
IKDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEAGTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKY
IKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLP
ELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVHPTKQEVRLSKERELMTLISK
AIDEALSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNNPLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTV
NQPETGSVSEKITDRTVESSNEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHA
AQERIKYEYWKDKIGEVSIEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSI
NEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLRELATCKNPYSCAHGRPTIVHFSGDDIQKMFRR
IQETHRSKAASWKDFE

Nucleotide


Download         Length: 1971 bp        

>NTDB_id=51701 KW2_RS11275 WP_021037999.1 2341575..2343545(-) (hexB) [Lactococcus cremoris subsp. cremoris KW2]
GTGGGAAAAATTATTGAACTAAATGAAGCGCTCGCCAATCAAATTGCTGCTGGAGAGGTGGTTGAGCGGCCTGCTAGTGT
TGTCAAAGAATTAGTCGAAAACTCAATTGATGCTGGAAGCAGTAAAATTATTATCAATGTTGAAGAAGCAGGTTTGCGAT
TAATTGAAGTCACAGATAATGGTTTGGGCTTAGAAAAAGAAGATGTGGCTTTGGCTTTGCGTCGTCATGCGACAAGTAAA
ATCAAAGATTCAGCTGATTTATTTCGAATTAGAACGCTCGGTTTTCGGGGTGAGGCTCTGCCGTCAATCGCTTCTGTCAG
CCAGATGACGATTGAAACAAGTAATGCTCAGGAAGAAGCTGGGACAAAACTGATTGCCAAAGGTGGGACGATTGAAACTT
TAGAACCACTTGCAAAGCGGTTAGGGACAAAAATTTCTGTTGCGAATCTTTTTTATAATACACCAGCAAGGCTCAAGTAT
ATCAAGTCTTTACAGGCTGAACTTTCTCATATTACAGATATTATCAATCGTTTGAGCCTCGCTCATCCAGAGATTTCTTT
TACTTTAGTTAATGAGGGTAAAGAATTTTTGAAAACGGCGGGAAATGGAGACTTGCGCCAAGTGATTGCTGCAATTTATG
GCATTGGAACGGCGAAAAAAATGCGTGAGATTAATGGCTCGGACTTAGATTTTGAACTGACAGGTTATGTCAGTTTACCC
GAGCTGACAAGAGCGAATCGTAACTATATCACGATTTTGATTAATGGTCGATTTATCAAGAATTTTTTGTTGAATCGAGC
AATTTTAGAAGGTTACGGGAACCGATTGATGGTTGGACGTTTTCCTTTTGCTGTTTTATCAATTAAAATTGACCCTAAAT
TAGCAGATGTCAATGTCCATCCGACAAAACAAGAAGTACGTTTGTCTAAGGAACGTGAATTGATGACTTTAATTTCTAAA
GCGATTGATGAGGCCTTATCAGAAGGGGTTTTGATTCCAGAAGCTTTGGAAAATTTGCAAGGTAGAGCCAAGGAAAAGGG
GACTGTTTCTGTTCAAACGGAACTTCCTTTACAGAATAATCCTTTATACTATGACAATGTTCGTCAAGATTTTTTTGTCA
GAGAAGAAGCGATTTTTGAAATCAATAAAAACGATAATTCAGATTCTTTGACTGAACAAAATTCTACTGATTATACAGTT
AATCAGCCAGAAACTGGTTCTGTCAGTGAAAAAATTACGGACAGAACTGTCGAAAGTTCAAATGAATTTACTGACAGAAC
CCCAAAAAATTCTGTCAGTAACTTTGGAGTTGATTTTGATAATATTGAGAAGCTGAGTCAGCAATCAACTTTTCCCCAAC
TAGAATACTTGGCACAACTGCATGCGACTTATTTACTTTGTCAGTCAAAAGAGGGTCTTTATTTGGTTGACCAACATGCG
GCTCAGGAGCGAATCAAGTATGAATATTGGAAAGATAAAATCGGCGAAGTGAGCATAGAGCAACAAATTTTACTTGCGCC
ATATTTATTTACTTTACCCAAAAATGATTTTATTGTTTTAGCTGAGAAAAAGGATTTGTTACATGAAGCAGGGGTTTTCT
TGGAAGAATACGGAGAAAATCAATTCATATTAAGAGAACATCCGATTTGGTTAAAAGAAACTGAGATAGAGAAATCAATT
AATGAAATGATTGATATTATTCTCTCATCAAAAGAATTTTCACTCAAAAAATATCGGCATGATTTAGCCGCAATGGTTGC
TTGTAAAAGCTCAATCAAAGCCAACCATCCCCTTGATGCCGAGTCTGCTAGAGCTTTGCTTAGAGAATTAGCAACTTGTA
AAAATCCTTATAGTTGTGCGCATGGACGGCCAACGATTGTTCATTTTTCAGGAGATGACATTCAAAAAATGTTCCGCAGA
ATCCAAGAAACGCATCGTTCAAAAGCGGCCTCTTGGAAAGATTTTGAGTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(455-598)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-119)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

57.599

100

0.578

Multiple sequence alignment