Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   I6H77_RS06345 Genome accession   NZ_CP066021
Coordinates   1306836..1307498 (-) Length   220 a.a.
NCBI ID   WP_000566511.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1306392..1321857 1306836..1307498 within 0


Gene organization within MGE regions


Location: 1306392..1321857
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS06340 (I6H77_06340) - 1306392..1306847 (+) 456 WP_000682683.1 effector binding domain-containing protein -
  I6H77_RS06345 (I6H77_06345) cclA/cilC 1306836..1307498 (-) 663 WP_000566511.1 prepilin peptidase Machinery gene
  I6H77_RS06350 (I6H77_06350) - 1307568..1308023 (+) 456 WP_000155446.1 GNAT family N-acetyltransferase -
  I6H77_RS09445 - 1308127..1308640 (+) 514 Protein_1208 thiol-disulfide isomerase -
  I6H77_RS06365 (I6H77_06365) - 1308710..1309231 (+) 522 WP_002874801.1 hypothetical protein -
  I6H77_RS06370 (I6H77_06370) - 1309449..1309652 (-) 204 WP_000102421.1 CsbD family protein -
  I6H77_RS06375 (I6H77_06375) - 1309694..1310278 (-) 585 WP_000072930.1 Asp23/Gls24 family envelope stress response protein -
  I6H77_RS06380 (I6H77_06380) - 1310290..1310460 (-) 171 WP_000454669.1 DUF2273 domain-containing protein -
  I6H77_RS06385 (I6H77_06385) amaP 1310471..1311034 (-) 564 WP_000045616.1 alkaline shock response membrane anchor protein AmaP -
  I6H77_RS06390 (I6H77_06390) - 1311134..1311370 (-) 237 WP_000964740.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  I6H77_RS06395 (I6H77_06395) - 1311667..1313148 (+) 1482 WP_001205297.1 M protein trans-acting positive regulator PRD domain-containing protein -
  I6H77_RS06400 (I6H77_06400) - 1313605..1314750 (-) 1146 WP_000209254.1 low temperature requirement protein A -
  I6H77_RS06405 (I6H77_06405) - 1315444..1315959 (-) 516 WP_000672739.1 DUF308 domain-containing protein -
  I6H77_RS06415 (I6H77_06415) - 1316651..1317922 (-) 1272 WP_001113188.1 replication-associated recombination protein A -
  I6H77_RS06420 (I6H77_06420) - 1318038..1318508 (+) 471 WP_000257122.1 DUF3013 family protein -
  I6H77_RS06425 (I6H77_06425) - 1318543..1320027 (+) 1485 WP_000664191.1 DUF262 domain-containing protein -
  I6H77_RS06430 (I6H77_06430) - 1320009..1321100 (+) 1092 WP_001122753.1 AAA family ATPase -
  I6H77_RS06435 (I6H77_06435) - 1321102..1321857 (+) 756 WP_000680882.1 hypothetical protein -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 25410.76 Da        Isoelectric Point: 8.3737

>NTDB_id=516488 I6H77_RS06345 WP_000566511.1 1306836..1307498(-) (cclA/cilC) [Streptococcus oralis strain FDAARGOS_1020]
MIDLYFFLVGSILASFLGLIIDRFPEQSIIRPASYCNSCQTRLRPLDLIPILSQVFNRFRCRYCKIRYPFWYALFELGLG
ILFLAWSWGWISLGQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILMAFCSWNLVMVFFLILGIMAHFIDIRMGAGDFL
FLASCALIFSATELLILIQFASAAGILAFLLQKKKERLPFVPFLLLAATIIIFYQFLLVC

Nucleotide


Download         Length: 663 bp        

>NTDB_id=516488 I6H77_RS06345 WP_000566511.1 1306836..1307498(-) (cclA/cilC) [Streptococcus oralis strain FDAARGOS_1020]
ATGATTGATCTTTATTTTTTTCTTGTCGGGAGCATTCTCGCTTCTTTCTTGGGTTTGATCATTGACCGTTTCCCTGAGCA
ATCCATTATTCGACCGGCTAGCTACTGCAATTCCTGTCAGACTCGCTTGCGACCCTTAGATTTGATTCCTATCCTTTCGC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAGATTCGATATCCATTCTGGTATGCCCTCTTTGAACTCGGCTTAGGA
ATCCTCTTTCTAGCTTGGTCTTGGGGCTGGATTTCCTTGGGTCAAGTCATCCTCATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTAGTCTGGATGACTTTCCACCTAATCCTCATGGCTTTCTGTAGTTGGA
ATCTGGTTATGGTCTTCTTCCTTATACTTGGAATCATGGCCCATTTTATCGATATTCGCATGGGCGCAGGGGATTTTCTC
TTTCTAGCTTCTTGTGCTCTCATCTTTAGCGCGACAGAATTACTCATCTTGATTCAGTTCGCTTCTGCGGCAGGCATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCGACTATAATAATTTTCT
ATCAGTTCTTATTAGTTTGTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-88)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus mitis SK321

87.215

99.545

0.868
  cclA/cilC Streptococcus pneumoniae Rx1

86.301

99.545

0.859
  cclA/cilC Streptococcus pneumoniae D39

86.301

99.545

0.859
  cclA/cilC Streptococcus pneumoniae R6

86.301

99.545

0.859
  cclA/cilC Streptococcus mitis NCTC 12261

85.845

99.545

0.855
  cclA/cilC Streptococcus pneumoniae TIGR4

85.388

99.545

0.85