Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   JAN99_RS07600 Genome accession   NZ_CP065927
Coordinates   1548407..1549093 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm9ST603     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1543407..1554093
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JAN99_RS07580 (JAN99_07575) dnaI 1544128..1545030 (-) 903 WP_002991016.1 primosomal protein DnaI -
  JAN99_RS07585 (JAN99_07580) - 1545031..1546206 (-) 1176 WP_032465854.1 replication initiation and membrane attachment family protein -
  JAN99_RS07590 (JAN99_07585) nrdR 1546190..1546684 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  JAN99_RS07595 (JAN99_07590) covS 1546899..1548401 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  JAN99_RS07600 (JAN99_07595) covR 1548407..1549093 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  JAN99_RS07605 (JAN99_07600) - 1549360..1549893 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  JAN99_RS07610 (JAN99_07605) htpX 1550127..1551023 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  JAN99_RS07615 (JAN99_07610) - 1551070..1551627 (-) 558 WP_002985956.1 LemA family protein -
  JAN99_RS07620 (JAN99_07615) rsmG 1551777..1552490 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  JAN99_RS07625 (JAN99_07620) ktrB 1552575..1553951 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=515382 JAN99_RS07600 WP_002991052.1 1548407..1549093(-) (covR) [Streptococcus pyogenes strain emm9ST603]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=515382 JAN99_RS07600 WP_002991052.1 1548407..1549093(-) (covR) [Streptococcus pyogenes strain emm9ST603]
ATGACAAAGAAGATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425