Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SIR_RS18990 Genome accession   NC_022246
Coordinates   1894873..1896819 (-) Length   648 a.a.
NCBI ID   WP_021003321.1    Uniprot ID   T1ZI05
Organism   Streptococcus intermedius B196     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1889873..1901819
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS20255 - 1891255..1891576 (+) 322 Protein_1794 transposase -
  SIR_RS18965 (SIR_1806) - 1891649..1892306 (-) 658 Protein_1795 CPBP family intramembrane glutamic endopeptidase -
  SIR_RS18970 (SIR_1807) - 1892311..1892865 (-) 555 WP_021003317.1 DNA-3-methyladenine glycosylase I -
  SIR_RS18975 (SIR_1808) ruvA 1892876..1893466 (-) 591 WP_021003318.1 Holliday junction branch migration protein RuvA Machinery gene
  SIR_RS18980 (SIR_1809) - 1893728..1894234 (+) 507 WP_021003319.1 helix-turn-helix domain-containing protein -
  SIR_RS18985 (SIR_1810) - 1894218..1894727 (+) 510 WP_041787616.1 RDD family protein -
  SIR_RS18990 (SIR_1811) hexB 1894873..1896819 (-) 1947 WP_021003321.1 DNA mismatch repair endonuclease MutL Machinery gene
  SIR_RS18995 (SIR_1812) brsR 1897061..1897501 (+) 441 WP_041787618.1 LytTR family DNA-binding domain-containing protein Regulator
  SIR_RS19000 (SIR_1813) - 1897498..1897956 (+) 459 WP_021003323.1 DUF3021 domain-containing protein -
  SIR_RS19005 (SIR_1814) hexA 1898097..1900655 (-) 2559 WP_021003324.1 DNA mismatch repair protein MutS Machinery gene
  SIR_RS19010 (SIR_1815) argR 1900818..1901258 (-) 441 WP_003075336.1 arginine repressor -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73421.97 Da        Isoelectric Point: 5.1595

>NTDB_id=51166 SIR_RS18990 WP_021003321.1 1894873..1896819(-) (hexB) [Streptococcus intermedius B196]
MSKIIELPEKLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLKSIQVIDNGEGIEHEEVPLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSCLTIETATETDQYGTLLVARGGEIECVEPTSSTVGTKIKVENLFFNTPARLKY
MKSQQAELSHIVDVMNRLSLAHPEIAFTLINDGKKMTQTVGTGNLRQAIAGVYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEYDLIPDALENLAKSTINRVSKPEQTSLPLKENRLYYDQGRTDFFVKPQVSEDRPSFEKTDQLAQQPVAPDMP
DSRTVSIKFAERQAPSYDQLDHPELDQASMERALEKLDREGISTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYRDKIGDVDDSQQQLLVPYIFEFPADDMLRLQQRMSLLEEVGIFLEEYGVNQFILREHPIWLKEEEIESGVYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCNNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=51166 SIR_RS18990 WP_021003321.1 1894873..1896819(-) (hexB) [Streptococcus intermedius B196]
ATGTCAAAAATTATAGAATTACCAGAAAAACTTGCCAATCAGATTGCAGCAGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAAAACTCCATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCAGGTCTCAAGA
GTATTCAAGTCATTGATAATGGCGAAGGAATTGAGCATGAGGAAGTTCCCTTAGCTTTGCGTCGGCATGCGACGAGTAAG
ATTAAGAAACAAGCCGACCTTTTTCGAATTCGGACGTTGGGTTTTCGCGGTGAGGCCCTTCCATCTATCGCTTCCGTTTC
ATGTTTGACGATTGAAACTGCAACAGAGACAGATCAATATGGTACTCTCTTGGTAGCCCGAGGTGGTGAAATTGAGTGTG
TAGAACCAACGAGCAGCACTGTCGGAACAAAAATCAAAGTCGAAAATCTCTTTTTCAATACACCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCCGAATTATCTCATATTGTAGATGTGATGAATCGTTTAAGTTTAGCCCATCCGGAGATTGCTTT
TACTCTAATAAATGACGGTAAAAAAATGACACAAACAGTAGGAACAGGGAATCTACGCCAAGCGATTGCTGGTGTTTATG
GATTGACAACGGCAAAAAAAATGATTGAGATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGCCTGCCA
GAACTAACACGAGCTAATCGTAATTATATCACGATTCTCATCAATGGTCGCTATATTAAGAATTTCTTGCTCAATCGAGC
TATCCTTGATGGCTATGGTAGTAAGCTCATGGTGGGGCGTTTTCCGATTGCAGTGATTGCTATTCAGATTGATCCTTACC
TTGCTGATGTCAATGTTCATCCCACTAAGCAAGAAGTACGGATCTCAAAAGAGCGAGAGCTTATGGTCTTGATTTCACAA
GCGATTGCTGCGAGTCTAAAAGAGTATGATTTGATTCCAGATGCTTTGGAGAATTTAGCCAAATCAACTATTAATCGAGT
AAGTAAGCCTGAACAGACTAGCCTACCACTAAAGGAGAACCGACTTTATTACGACCAAGGAAGAACCGATTTCTTTGTGA
AACCACAAGTGTCAGAAGATCGACCTTCTTTTGAGAAAACTGACCAATTAGCTCAGCAACCCGTTGCTCCAGATATGCCT
GATTCCAGAACAGTCTCTATTAAATTTGCAGAAAGGCAGGCGCCTTCTTATGACCAACTGGATCATCCTGAGTTAGATCA
AGCTAGTATGGAGAGAGCTTTAGAGAAGCTAGATAGAGAAGGAATATCAACCTTTCCAGAGTTGGAATATTTCGGTCAAA
TGCATGGCACCTATCTCTTTGCACAAGGAAATGGTGGCCTTTACATTATTGACCAGCATGCGGCTCAAGAACGAGTCAAG
TATGAATATTATAGGGACAAAATAGGAGATGTAGATGACAGTCAGCAACAGCTTTTGGTACCTTATATTTTTGAATTTCC
GGCAGACGATATGTTGCGACTTCAACAACGAATGTCTCTTTTGGAAGAAGTGGGTATTTTCCTAGAAGAATATGGAGTCA
ATCAATTTATTTTGCGTGAACATCCTATTTGGCTCAAAGAAGAGGAAATTGAGTCAGGTGTCTATGAAATGTGTGACATG
CTGCTTTTGACCAAGGAAGTCTCTATTAAGAAATATCGTGCAGAGCTAGCTATTATGATGAGCTGTAAACGTTCTATTAA
GGCCAATCATAGCTTAGATGACTACTCGGCACGTGATTTAATTTTCCAACTATCACAATGCAACAATCCTTATAACTGTC
CACATGGTCGACCAGTTTTGGTTAACTTTACCAAGTCGGATATGGAAAAAATGTTTCGCCGCATTCAGGAAAATCATACT
AGCCTACGGGAGTTGGGTAAGTATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZI05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.576

100

0.759

Multiple sequence alignment