Detailed information NTG0051168

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SIR_RS19005
• Genome accession: NC_022246
• Coordinates: 1898097..1900655 (-)
• Length: 852 a.a.
• NCBI ID: WP_021003324.1
• Uniprot ID: T1ZH40
• Organism: Streptococcus intermedius B196
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1893097..1905655

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SIR_RS18980 (SIR_1809)	-	1893728..1894234 (+)	507	WP_021003319.1	helix-turn-helix domain-containing protein	-
SIR_RS18985 (SIR_1810)	-	1894218..1894727 (+)	510	WP_041787616.1	RDD family protein	-
SIR_RS18990 (SIR_1811)	hexB	1894873..1896819 (-)	1947	WP_021003321.1	DNA mismatch repair endonuclease MutL	Machinery gene
SIR_RS18995 (SIR_1812)	brsR	1897061..1897501 (+)	441	WP_041787618.1	LytTR family DNA-binding domain-containing protein	Regulator
SIR_RS19000 (SIR_1813)	-	1897498..1897956 (+)	459	WP_021003323.1	DUF3021 domain-containing protein	-
SIR_RS19005 (SIR_1814)	hexA	1898097..1900655 (-)	2559	WP_021003324.1	DNA mismatch repair protein MutS	Machinery gene
SIR_RS19010 (SIR_1815)	argR	1900818..1901258 (-)	441	WP_003075336.1	arginine repressor	-
SIR_RS19015 (SIR_1816)	argS	1901362..1903050 (+)	1689	WP_021003325.1	arginine--tRNA ligase	-
SIR_RS19020 (SIR_1817)	nrdI	1903102..1903557 (-)	456	WP_009569662.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
SIR_RS19025 (SIR_1818)	-	1903633..1904142 (-)	510	WP_021003326.1	hypothetical protein	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 96214.67 Da
• Isoelectric Point: 4.9651

>NTDB_id=51168 SIR_RS19005 WP_021003324.1 1898097..1900655(-) (hexA) [Streptococcus intermedius B196]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAINAAQILEIALTSRNKNSEKPIPMAGVPYHSVQQYIDVLI
ESGYKVAIAEQVEDPKKAVGVVKREVVQVITPGTAVDSSKPDSQNNFLVALDKLEDFYGLAYMDVVTGEFQVTTLSDFNM
VCGEIRNLRAREVVLGYELPEAEHQVLANQMNLLLSQVETAFEDVQLLGDDLSRLEYQVAGKLLEYVHQTQLRELSHLKR
VHHYEIKDFLQMNYATMTSLDLTENARTGKKHGSLYWLMDETKTAMGMRLLRRWIQHPLLDKERILKRQDVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSNVPQIKGILQGIDHPVLGQLIENLDDIPELANLIQSAISP
DAPNVITEGNIIQTGFDETLDKYRVVLRDGTSWIADIEAKERVASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFIRIREEAGKYIKRLQSLAQTLATVDVLQSFAAVAEKQHFVRPEFI
ERPSIEIDKGRHAVVEKVMGAQTYIPNSISMDENVNLQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVSAERAQLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANHAISQATEHSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TDLSTSLTQLENVHVATLEKDGQVTFLHKIEAGPADKSYGIHVARIAGLPNDLLMRADQILARLEEQANEKPSLNPSNKG
ANDSKENQVSEQISLFTETTESPILDELRQLDIYNMTPMEVMLAIAEMKKHL

Nucleotide

• Length: 2559 bp

>NTDB_id=51168 SIR_RS19005 WP_021003324.1 1898097..1900655(-) (hexA) [Streptococcus intermedius B196]
ATGACAAAAGAAAAACTATCTCCGGGGATGCAACAGTATTTAGATATAAAAAAAGATTATCCAGATGCTTTTTTGCTATT
TCGCATGGGAGATTTTTATGAATTATTCTATGAAGATGCGATCAATGCAGCACAGATTTTAGAAATTGCTCTGACTAGCC
GTAATAAAAATTCGGAAAAGCCAATCCCGATGGCAGGAGTTCCCTATCATTCGGTGCAACAATATATTGATGTTTTAATT
GAATCGGGCTATAAAGTAGCGATTGCAGAGCAGGTGGAAGATCCTAAAAAAGCAGTTGGTGTAGTCAAACGTGAGGTGGT
ACAAGTCATCACACCGGGGACAGCCGTTGATTCTTCAAAACCAGATAGTCAAAATAATTTCTTGGTAGCTTTAGATAAGC
TAGAAGATTTCTATGGGCTAGCTTATATGGATGTGGTAACTGGTGAATTTCAGGTGACAACTCTCAGTGACTTTAACATG
GTTTGTGGGGAAATTCGAAATCTACGAGCGCGTGAAGTGGTGTTGGGATATGAATTACCTGAAGCAGAGCACCAAGTGTT
GGCAAATCAAATGAATTTGTTATTATCACAGGTGGAAACAGCTTTTGAAGATGTTCAGCTATTAGGAGATGATTTGTCTC
GCCTAGAATATCAAGTAGCTGGGAAACTGTTAGAATATGTTCACCAGACGCAACTGCGTGAGCTTAGTCACTTAAAGCGA
GTTCATCATTATGAAATTAAAGATTTCTTACAGATGAACTATGCAACTATGACAAGTCTAGATTTAACGGAGAATGCACG
GACGGGGAAGAAGCATGGCAGTCTTTATTGGTTGATGGATGAGACGAAGACAGCTATGGGGATGCGACTTCTAAGAAGAT
GGATCCAGCATCCGTTGCTTGATAAGGAACGGATTCTTAAGCGACAGGATGTCGTACAAGTCTTTTTAGATCATTTTTTT
GAGCGTAGTGATTTGACAGATAGTCTCAAAGGGGTTTATGATATTGAGCGCTTGGCAAGCCGTGTTTCTTTTGGGAAGAC
AAACCCGAAGGATTTATTGCAGTTGGCGGCAACATTGAGCAATGTCCCTCAGATTAAGGGAATTTTACAAGGAATCGATC
ATCCTGTTTTGGGACAGTTGATTGAAAACTTGGATGATATTCCAGAATTGGCAAATTTGATTCAGTCGGCAATTTCTCCT
GATGCTCCAAATGTTATTACTGAAGGGAATATCATTCAAACTGGTTTTGATGAAACCTTAGATAAGTATCGAGTGGTTCT
GCGAGATGGTACAAGCTGGATTGCCGATATTGAAGCGAAAGAAAGGGTGGCTAGTGGGATTAATAATCTAAAAATTGATT
ACAATAAAAAAGACGGTTATTATTTCCATGTTACTAATTCACAGTTGGAGCACGTACCTAGCCACTTTTTCCGAAAAGCA
ACGTTGAAAAATTCAGAACGATTTGGTACAGAGGAATTGGCTCGTATTGAAGGCGAAATGTTGGAAGCGCGTGAAAAATC
GGCCAATTTAGAGTATGAGATTTTTATACGTATTCGGGAAGAAGCTGGCAAATATATCAAACGATTACAATCCTTGGCAC
AAACTCTAGCAACAGTGGATGTATTGCAGAGTTTTGCAGCAGTTGCTGAAAAGCAACACTTTGTACGCCCAGAATTTATT
GAACGTCCTTCCATTGAAATCGATAAAGGACGGCATGCAGTTGTAGAAAAGGTTATGGGCGCACAAACTTATATTCCGAA
TAGTATTTCAATGGACGAGAATGTCAATCTTCAGCTAATTACAGGTCCAAATATGAGTGGGAAGTCAACCTATATGCGTC
AATTAGCGATTATTGTTATCATGGCGCAAATGGGTTCCTATGTTTCAGCTGAACGTGCTCAATTACCAATTTTTGATGCC
ATCTTCACTCGAATTGGTGCAGCAGATGACTTGGTATCTGGGCAATCAACCTTTATGGTAGAAATGATGGAAGCAAATCA
TGCTATTTCTCAGGCGACTGAACACTCTCTTATTCTTTTTGATGAGTTGGGAAGAGGGACAGCAACATATGATGGGATGG
CTCTTGCTCAGGCGATTATTGAATATATCCACAATCGAACAGGAGCAAAGACCCTTTTTGCCACACACTATCATGAGTTG
ACAGACTTGTCAACTAGCTTGACACAGTTAGAAAATGTTCATGTAGCAACTTTAGAAAAAGATGGGCAAGTGACCTTCCT
TCATAAGATTGAAGCTGGTCCTGCAGATAAGTCTTATGGGATTCATGTCGCAAGAATTGCAGGTTTACCAAATGATTTGT
TGATGAGAGCCGACCAGATACTAGCAAGACTAGAAGAACAAGCAAATGAGAAACCATCTCTCAATCCTTCTAATAAAGGA
GCTAATGATAGCAAGGAAAATCAAGTATCTGAGCAGATATCTTTATTCACAGAAACAACTGAATCCCCTATTTTAGATGA
ACTACGTCAGTTGGATATTTATAATATGACCCCAATGGAAGTGATGCTAGCTATAGCTGAGATGAAAAAACATCTCTGA

Domains

Predicted by InterProScan.

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (255-546)

• MutS domain I (MutS_I) (8-118)

3D structure

• AlphaFold DB: T1ZH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	75.704	100	0.757
mutS	Pseudomonas stutzeri strain ATCC 17587	36.195	100	0.366