NTDB

Overview

Name	covR	Type	Regulator
Locus tag	ST4134_RS01665	Genome accession	NZ_CP065478
Coordinates	298636..299325 (+)	Length	229 a.a.
NCBI ID	WP_002949638.1	Uniprot ID	A0A060BFD8
Organism	Streptococcus thermophilus strain 4134
Function	repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 293636..304325

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4134_RS01640	-	294602..294772 (+)	171	Protein_270	ascorbate 6-phosphate lactonase	-
ST4134_RS01645 (ST4134_01635)	-	294789..295460 (-)	672	WP_002946492.1	TrkA family potassium uptake protein	-
ST4134_RS01650 (ST4134_01640)	-	295500..296864 (-)	1365	WP_011680735.1	TrkH family potassium uptake protein	-
ST4134_RS01655 (ST4134_01645)	rsmG	296934..297647 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
ST4134_RS01660 (ST4134_01650)	-	297944..298480 (+)	537	WP_014607968.1	DUF177 domain-containing protein	-
ST4134_RS01665 (ST4134_01655)	covR	298636..299325 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
ST4134_RS01670 (ST4134_01660)	covS	299322..300839 (+)	1518	WP_002949640.1	HAMP domain-containing histidine kinase	Regulator
ST4134_RS01675 (ST4134_01665)	nrdR	300961..301440 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
ST4134_RS01680 (ST4134_01670)	-	301437..302612 (+)	1176	WP_011680739.1	DnaD domain protein	-
ST4134_RS01685 (ST4134_01675)	dnaI	302616..303518 (+)	903	WP_014607971.1	primosomal protein DnaI	-

Sequence

Protein

Download Length: 229 a.a. Molecular weight: 26655.77 Da Isoelectric Point: 4.7059

                                >NTDB_id=510050 ST4134_RS01665 WP_002949638.1 298636..299325(+) (covR) [Streptococcus thermophilus strain 4134]

MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT

ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE

FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide

Download Length: 690 bp

                                >NTDB_id=510050 ST4134_RS01665 WP_002949638.1 298636..299325(+) (covR) [Streptococcus thermophilus strain 4134]

ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA

CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC

TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA

GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA

AGAACTGTTGGCACGTATTCGTGCAACTTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA

CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG

TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA

TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT

CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Streptococcus salivarius strain HSISS4	96.07	100	0.961
covR	Lactococcus lactis subsp. lactis strain DGCC12653	67.544	99.563	0.672
vicR	Streptococcus mutans UA159	45.259	100	0.459
micA	Streptococcus pneumoniae Cp1015	43.913	100	0.441

Detailed information NTG0510050