NTDB

Overview

Name	covR	Type	Regulator
Locus tag	ST4052_RS01640	Genome accession	NZ_CP065476
Coordinates	297911..298600 (+)	Length	229 a.a.
NCBI ID	WP_002949638.1	Uniprot ID	A0A060BFD8
Organism	Streptococcus thermophilus strain 4052
Function	repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 292911..303600

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4052_RS01615	-	293877..294047 (+)	171	Protein_265	ascorbate 6-phosphate lactonase	-
ST4052_RS01620 (ST4052_01635)	-	294064..294735 (-)	672	WP_002946492.1	TrkA family potassium uptake protein	-
ST4052_RS01625 (ST4052_01640)	-	294775..296139 (-)	1365	WP_269473675.1	potassium transporter TrkG	-
ST4052_RS01630 (ST4052_01645)	rsmG	296209..296922 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
ST4052_RS01635 (ST4052_01650)	-	297219..297755 (+)	537	WP_002946488.1	YceD family protein	-
ST4052_RS01640 (ST4052_01655)	covR	297911..298600 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
ST4052_RS01645 (ST4052_01660)	covS	298597..300114 (+)	1518	WP_059257356.1	HAMP domain-containing histidine kinase	Regulator
ST4052_RS01650 (ST4052_01665)	nrdR	300236..300715 (+)	480	WP_002949642.1	transcriptional regulator NrdR	-
ST4052_RS01655 (ST4052_01670)	-	300712..301887 (+)	1176	WP_011225482.1	DnaD domain protein	-
ST4052_RS01660 (ST4052_01675)	dnaI	301891..302793 (+)	903	WP_002946786.1	primosomal protein DnaI	-

Sequence

Protein

Download Length: 229 a.a. Molecular weight: 26655.77 Da Isoelectric Point: 4.7059

                                >NTDB_id=509934 ST4052_RS01640 WP_002949638.1 297911..298600(+) (covR) [Streptococcus thermophilus strain 4052]

MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT

ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE

FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide

Download Length: 690 bp

                                >NTDB_id=509934 ST4052_RS01640 WP_002949638.1 297911..298600(+) (covR) [Streptococcus thermophilus strain 4052]

ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA

CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC

TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA

GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA

AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA

CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG

TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA

TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT

CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Streptococcus salivarius strain HSISS4	96.07	100	0.961
covR	Lactococcus lactis subsp. lactis strain DGCC12653	67.544	99.563	0.672
vicR	Streptococcus mutans UA159	45.259	100	0.459
micA	Streptococcus pneumoniae Cp1015	43.913	100	0.441

Detailed information NTG0509934