Detailed information NTG0050844

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MYY_RS09855
• Genome accession: NC_017769
• Coordinates: 1863974..1865011 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae ST556
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1858974..1870011

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MYY_RS09830 (MYY_1886)	-	1859713..1861044 (-)	1332	WP_000390039.1	hemolysin family protein	-
MYY_RS09835 (MYY_1887)	endA	1861335..1862159 (-)	825	WP_001036785.1	DNA-entry nuclease EndA	Machinery gene
MYY_RS09840 (MYY_1888)	-	1862198..1862386 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
MYY_RS09845 (MYY_1889)	murA	1862379..1863662 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
MYY_RS09850	-	1863686..1863916 (-)	231	WP_000250392.1	DUF1146 family protein	-
MYY_RS09855 (MYY_1890)	sepM	1863974..1865011 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
MYY_RS09860 (MYY_1891)	coaD	1864995..1865483 (-)	489	WP_001280731.1	pantetheine-phosphate adenylyltransferase	-
MYY_RS09865 (MYY_1892)	rsmD	1865473..1866012 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MYY_RS09870 (MYY_1893)	asnA	1866077..1867069 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
MYY_RS09875 (MYY_1894)	-	1867180..1867863 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
MYY_RS09880 (MYY_1895)	-	1867919..1868659 (-)	741	WP_000152692.1	TrmH family RNA methyltransferase	-
MYY_RS09885 (MYY_1896)	-	1868693..1868971 (+)	279	WP_001174613.1	acylphosphatase	-
MYY_RS09890 (MYY_1897)	yidC	1869049..1869975 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=50844 MYY_RS09855 WP_000727277.1 1863974..1865011(-) (sepM) [Streptococcus pneumoniae ST556]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=50844 MYY_RS09855 WP_000727277.1 1863974..1865011(-) (sepM) [Streptococcus pneumoniae ST556]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCCATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591