Detailed information
Bioinformatically predicted
Overview
| Name | ciaH | Type | Regulator |
| Locus tag | I2436_RS04605 | Genome accession | NZ_CP065060 |
| Coordinates | 980053..981363 (+) | Length | 436 a.a. |
| NCBI ID | WP_014622812.1 | Uniprot ID | - |
| Organism | Streptococcus equi subsp. zooepidemicus strain SEZ28 | ||
| Function | Required for optimal comC expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 951328..1001358 | 980053..981363 | within | 0 |
Gene organization within MGE regions
Location: 951328..1001358
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I2436_RS04460 (GDAKBCAL_00888) | - | 951409..952743 (-) | 1335 | WP_111710538.1 | sodium:alanine symporter family protein | - |
| I2436_RS04465 (GDAKBCAL_00889) | pcrA | 953223..955514 (+) | 2292 | WP_012679460.1 | DNA helicase PcrA | - |
| I2436_RS04470 (GDAKBCAL_00890) | - | 955928..956173 (+) | 246 | WP_021320695.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| I2436_RS04475 (GDAKBCAL_00891) | amaP | 956221..956802 (+) | 582 | WP_012515522.1 | alkaline shock response membrane anchor protein AmaP | - |
| I2436_RS04480 (GDAKBCAL_00892) | - | 956812..957000 (+) | 189 | WP_012515523.1 | DUF2273 domain-containing protein | - |
| I2436_RS04485 (GDAKBCAL_00893) | - | 957013..957552 (+) | 540 | WP_012515524.1 | Asp23/Gls24 family envelope stress response protein | - |
| I2436_RS04490 (GDAKBCAL_00894) | - | 957590..957787 (+) | 198 | WP_012678035.1 | CsbD family protein | - |
| I2436_RS04495 (GDAKBCAL_00895) | - | 957797..958285 (+) | 489 | WP_012515526.1 | Asp23/Gls24 family envelope stress response protein | - |
| I2436_RS04500 (GDAKBCAL_00896) | - | 958441..959082 (+) | 642 | WP_012678034.1 | TrkA C-terminal domain-containing protein | - |
| I2436_RS04505 (GDAKBCAL_00897) | - | 959199..959747 (-) | 549 | WP_206153183.1 | TetR/AcrR family transcriptional regulator | - |
| I2436_RS04510 (GDAKBCAL_00898) | - | 959870..960571 (+) | 702 | WP_154803878.1 | ABC transporter ATP-binding protein | - |
| I2436_RS04515 (GDAKBCAL_00899) | - | 960583..963222 (+) | 2640 | WP_206153184.1 | ABC transporter permease | - |
| I2436_RS04520 (GDAKBCAL_00900) | - | 963298..963894 (+) | 597 | WP_206153185.1 | restriction endonuclease subunit S | - |
| I2436_RS04525 (GDAKBCAL_00901) | - | 963904..964866 (+) | 963 | WP_012515532.1 | aromatic acid exporter family protein | - |
| I2436_RS04530 (GDAKBCAL_00902) | - | 964963..966300 (+) | 1338 | WP_012515533.1 | DUF2130 domain-containing protein | - |
| I2436_RS04535 (GDAKBCAL_00903) | truB | 966409..967290 (+) | 882 | WP_012515534.1 | tRNA pseudouridine(55) synthase TruB | - |
| I2436_RS04540 (GDAKBCAL_00904) | - | 967304..968236 (+) | 933 | WP_111721675.1 | bifunctional riboflavin kinase/FAD synthetase | - |
| I2436_RS04545 (GDAKBCAL_00905) | - | 968279..968683 (+) | 405 | WP_012678026.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| I2436_RS04550 (GDAKBCAL_00906) | - | 968685..968963 (+) | 279 | WP_043025768.1 | UPF0223 family protein | - |
| I2436_RS04555 (GDAKBCAL_00907) | - | 968953..969729 (+) | 777 | WP_111710544.1 | inositol monophosphatase family protein | - |
| I2436_RS04560 (GDAKBCAL_00908) | - | 969746..971053 (+) | 1308 | WP_206153187.1 | RsmF rRNA methyltransferase first C-terminal domain-containing protein | - |
| I2436_RS04565 (GDAKBCAL_00909) | - | 971191..972057 (+) | 867 | WP_012678022.1 | phosphate ABC transporter substrate-binding protein PstS family protein | - |
| I2436_RS04570 (GDAKBCAL_00910) | pstC | 972068..973003 (+) | 936 | WP_012515541.1 | phosphate ABC transporter permease subunit PstC | - |
| I2436_RS04575 (GDAKBCAL_00911) | pstA | 972993..973880 (+) | 888 | WP_012515542.1 | phosphate ABC transporter permease PstA | - |
| I2436_RS04580 (GDAKBCAL_00912) | pstB | 973897..974700 (+) | 804 | WP_012515543.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| I2436_RS04585 (GDAKBCAL_00913) | pstB | 974714..975472 (+) | 759 | WP_012678019.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| I2436_RS04590 (GDAKBCAL_00914) | phoU | 975543..976196 (+) | 654 | WP_012678018.1 | phosphate signaling complex protein PhoU | - |
| I2436_RS04595 (GDAKBCAL_00915) | - | 976430..978967 (+) | 2538 | WP_206153189.1 | M1 family metallopeptidase | - |
| I2436_RS04600 (GDAKBCAL_00916) | ciaR | 979386..980060 (+) | 675 | WP_021320708.1 | response regulator | Regulator |
| I2436_RS04605 (GDAKBCAL_00917) | ciaH | 980053..981363 (+) | 1311 | WP_014622812.1 | HAMP domain-containing sensor histidine kinase | Regulator |
| I2436_RS04610 (GDAKBCAL_00918) | - | 981748..982137 (+) | 390 | WP_206153191.1 | hypothetical protein | - |
| I2436_RS04615 (GDAKBCAL_00919) | - | 982307..982633 (+) | 327 | WP_014622820.1 | hypothetical protein | - |
| I2436_RS04620 (GDAKBCAL_00920) | - | 982635..982910 (+) | 276 | WP_206153193.1 | hypothetical protein | - |
| I2436_RS04625 (GDAKBCAL_00921) | - | 982926..983327 (+) | 402 | WP_042670593.1 | hypothetical protein | - |
| I2436_RS04630 (GDAKBCAL_00922) | - | 983329..983574 (+) | 246 | WP_206153262.1 | hypothetical protein | - |
| I2436_RS04635 (GDAKBCAL_00923) | - | 983590..983997 (+) | 408 | WP_014622815.1 | hypothetical protein | - |
| I2436_RS04640 (GDAKBCAL_00924) | - | 984007..984297 (+) | 291 | WP_021320713.1 | hypothetical protein | - |
| I2436_RS04645 (GDAKBCAL_00925) | - | 984221..984604 (+) | 384 | WP_012678013.1 | hypothetical protein | - |
| I2436_RS04650 (GDAKBCAL_00926) | - | 984606..984857 (+) | 252 | WP_043029681.1 | hypothetical protein | - |
| I2436_RS04655 (GDAKBCAL_00927) | - | 985032..985412 (+) | 381 | WP_043029682.1 | hypothetical protein | - |
| I2436_RS04660 (GDAKBCAL_00928) | - | 985409..985669 (+) | 261 | WP_206153195.1 | hypothetical protein | - |
| I2436_RS04665 (GDAKBCAL_00929) | - | 985685..986098 (+) | 414 | WP_037584321.1 | hypothetical protein | - |
| I2436_RS04670 (GDAKBCAL_00930) | - | 986099..987292 (+) | 1194 | WP_206153197.1 | hypothetical protein | - |
| I2436_RS04675 (GDAKBCAL_00931) | - | 987289..987681 (+) | 393 | WP_206153199.1 | hypothetical protein | - |
| I2436_RS04680 (GDAKBCAL_00932) | - | 987701..987985 (+) | 285 | WP_012677440.1 | hypothetical protein | - |
| I2436_RS04685 (GDAKBCAL_00933) | rpsT | 988184..988417 (-) | 234 | WP_037578328.1 | 30S ribosomal protein S20 | - |
| I2436_RS04690 (GDAKBCAL_00934) | - | 988595..989992 (+) | 1398 | WP_206153201.1 | ISNCY-like element ISSeq2 family transposase | - |
| I2436_RS04695 (GDAKBCAL_00935) | coaA | 990056..990976 (-) | 921 | WP_111710551.1 | type I pantothenate kinase | - |
| I2436_RS04700 (GDAKBCAL_00936) | - | 991243..991839 (+) | 597 | WP_021320719.1 | methyltransferase | - |
| I2436_RS04705 (GDAKBCAL_00937) | - | 991938..993215 (+) | 1278 | WP_043038949.1 | pyrimidine-nucleoside phosphorylase | - |
| I2436_RS04710 (GDAKBCAL_00938) | deoC | 993229..993891 (+) | 663 | WP_012515563.1 | deoxyribose-phosphate aldolase | - |
| I2436_RS04715 (GDAKBCAL_00939) | - | 993878..994267 (+) | 390 | WP_021320721.1 | cytidine deaminase | - |
| I2436_RS04720 (GDAKBCAL_00940) | - | 994358..995410 (+) | 1053 | WP_012515565.1 | BMP family protein | - |
| I2436_RS04725 (GDAKBCAL_00941) | - | 995537..997069 (+) | 1533 | WP_021320722.1 | ATP-binding cassette domain-containing protein | - |
| I2436_RS04730 (GDAKBCAL_00942) | - | 997062..998126 (+) | 1065 | WP_206153203.1 | ABC transporter permease | - |
| I2436_RS04735 (GDAKBCAL_00943) | - | 998128..999084 (+) | 957 | WP_111678071.1 | ABC transporter permease | - |
| I2436_RS04740 (GDAKBCAL_00944) | - | 999602..1001317 (-) | 1716 | WP_206153205.1 | phospho-sugar mutase | - |
Sequence
Protein
Download Length: 436 a.a. Molecular weight: 49604.24 Da Isoelectric Point: 9.6507
>NTDB_id=506543 I2436_RS04605 WP_014622812.1 980053..981363(+) (ciaH) [Streptococcus equi subsp. zooepidemicus strain SEZ28]
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGTIFEVKL
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGTIFEVKL
Nucleotide
Download Length: 1311 bp
>NTDB_id=506543 I2436_RS04605 WP_014622812.1 980053..981363(+) (ciaH) [Streptococcus equi subsp. zooepidemicus strain SEZ28]
ATGAATAAACTAAAAAAAGGATTATTGTCCGATAATTATACGCATTTTTTTCATTTCTTTGCTATTTTTACAGGCATTTT
TGTTGTCATGACCATCATTATTTTGCAAATCATGAGGTTTAGTGTCTATTCCACAGTAGACAGCAGTCTCATTTCGGTCG
GTCAAAATGCCAGCAACTATGCTAATAGGACCATGGCGAGAATATCTTCCTTTTATTTTGATGCAGAAAATAACCTTATT
CAGGCTCTTCCTGAACTGGAAGCGTCAAAATCACTTGGCTCCTCCACCACTAATATGGATATTATTTTATTTAGTGCTAA
TGGGACGATATTGAACTCCTTTGACGCTTTCTCTAATTACCAAAGCTTTCGTTTAGACAAAAGCCAGCTCAATAACATTG
TCACAACACAGCTGATGAATTTTTATGGGCAAAAGGAGAAATACCATACCCTAACTGTTAAGGTTCACATTAAAAACTAT
CCAGCAGTGGCTTATATGATGGCAGTGGTTAATGTTCAGCAGCTGGATACTGCTAATGAGCGCTATGAACAGATTATTAT
CATGGTTATGATTGTCTTTTGGTTAATTTCGATTTTGGCCAGTATTTATTTGGCTAAGTGGAGCAGAAAGCCAATTATGG
AGAGCTATGCCAAGCAAAAAATGTTTGTAGAAAATGCCAGTCATGAGCTTAGGACTCCTTTAGCGGTGCTGCAAAATCGT
TTGGAATCGCTGTTTAGAAAGCCTAACGAAACCATTTTAGACAATAGCGAGCATATTGCGTCAAGCCTAGATGAGGTTCG
TAATATGAGAATATTAACAACTAATCTGTTAAATTTAGCCAGACGTGATGATGGGATCAAGCCGCAGCTAGTTGATGTTG
ATGCAGCCTTTTTTGATACTGTTTTTGAAAATTATCAATTAGTTGCAGAAGAGTCAGGCAAGCAGTTTATCTCAGCTAAT
CAGATCAATAGGCCCTTAAAGACGGATAAGGCTTTGCTCAAGCAGCTGATGACCATTTTGTTTGATAATGCGATCAAATA
CACTGATCATAACGGTGTGGTTGAGGTCAAGGTTAGAACGACCGATAAGCATTTATTGATTTCTGTTATTGATAATGGCC
CAGGGATCAAGGATGATGATAAGAAAAAGATTTTTGATCGCTTTTACCGAGTGGATAAGGCAAGGACACGCCAAAAAGGA
GGCTTTGGACTCGGATTGGCCTTAGCGCAGCAGATCGTTACCTCATTAAAAGGAACGATTACCGTCAGTGATAATAAGCC
TACCGGTACCATATTTGAAGTAAAATTATAG
ATGAATAAACTAAAAAAAGGATTATTGTCCGATAATTATACGCATTTTTTTCATTTCTTTGCTATTTTTACAGGCATTTT
TGTTGTCATGACCATCATTATTTTGCAAATCATGAGGTTTAGTGTCTATTCCACAGTAGACAGCAGTCTCATTTCGGTCG
GTCAAAATGCCAGCAACTATGCTAATAGGACCATGGCGAGAATATCTTCCTTTTATTTTGATGCAGAAAATAACCTTATT
CAGGCTCTTCCTGAACTGGAAGCGTCAAAATCACTTGGCTCCTCCACCACTAATATGGATATTATTTTATTTAGTGCTAA
TGGGACGATATTGAACTCCTTTGACGCTTTCTCTAATTACCAAAGCTTTCGTTTAGACAAAAGCCAGCTCAATAACATTG
TCACAACACAGCTGATGAATTTTTATGGGCAAAAGGAGAAATACCATACCCTAACTGTTAAGGTTCACATTAAAAACTAT
CCAGCAGTGGCTTATATGATGGCAGTGGTTAATGTTCAGCAGCTGGATACTGCTAATGAGCGCTATGAACAGATTATTAT
CATGGTTATGATTGTCTTTTGGTTAATTTCGATTTTGGCCAGTATTTATTTGGCTAAGTGGAGCAGAAAGCCAATTATGG
AGAGCTATGCCAAGCAAAAAATGTTTGTAGAAAATGCCAGTCATGAGCTTAGGACTCCTTTAGCGGTGCTGCAAAATCGT
TTGGAATCGCTGTTTAGAAAGCCTAACGAAACCATTTTAGACAATAGCGAGCATATTGCGTCAAGCCTAGATGAGGTTCG
TAATATGAGAATATTAACAACTAATCTGTTAAATTTAGCCAGACGTGATGATGGGATCAAGCCGCAGCTAGTTGATGTTG
ATGCAGCCTTTTTTGATACTGTTTTTGAAAATTATCAATTAGTTGCAGAAGAGTCAGGCAAGCAGTTTATCTCAGCTAAT
CAGATCAATAGGCCCTTAAAGACGGATAAGGCTTTGCTCAAGCAGCTGATGACCATTTTGTTTGATAATGCGATCAAATA
CACTGATCATAACGGTGTGGTTGAGGTCAAGGTTAGAACGACCGATAAGCATTTATTGATTTCTGTTATTGATAATGGCC
CAGGGATCAAGGATGATGATAAGAAAAAGATTTTTGATCGCTTTTACCGAGTGGATAAGGCAAGGACACGCCAAAAAGGA
GGCTTTGGACTCGGATTGGCCTTAGCGCAGCAGATCGTTACCTCATTAAAAGGAACGATTACCGTCAGTGATAATAAGCC
TACCGGTACCATATTTGAAGTAAAATTATAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaH | Streptococcus mutans UA159 |
57.895 |
100 |
0.58 |
| ciaH | Streptococcus pneumoniae Rx1 |
51.606 |
100 |
0.516 |
| ciaH | Streptococcus pneumoniae D39 |
51.606 |
100 |
0.516 |
| ciaH | Streptococcus pneumoniae R6 |
51.606 |
100 |
0.516 |
| ciaH | Streptococcus pneumoniae TIGR4 |
51.606 |
100 |
0.516 |