Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   I2433_RS01985 Genome accession   NZ_CP065056
Coordinates   388251..388937 (+) Length   228 a.a.
NCBI ID   WP_012516253.1    Uniprot ID   U5Y8A0
Organism   Streptococcus equi subsp. zooepidemicus strain SEZ14     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 383251..393937
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I2433_RS01965 (JDBNIEOD_00383) rsmG 384913..385626 (-) 714 WP_012516257.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  I2433_RS01970 (JDBNIEOD_00384) - 385762..386319 (+) 558 WP_012677410.1 LemA family protein -
  I2433_RS01975 (JDBNIEOD_00385) htpX 386351..387244 (+) 894 WP_012516255.1 zinc metalloprotease HtpX -
  I2433_RS01980 (JDBNIEOD_00386) - 387532..388065 (+) 534 WP_012516254.1 DUF177 domain-containing protein -
  I2433_RS01985 (JDBNIEOD_00387) covR 388251..388937 (+) 687 WP_012516253.1 two-component system response regulator CovR Regulator
  I2433_RS01990 (JDBNIEOD_00388) - 388941..390431 (+) 1491 WP_206152380.1 HAMP domain-containing histidine kinase -
  I2433_RS01995 (JDBNIEOD_00389) nrdR 390622..391116 (+) 495 WP_012516251.1 transcriptional regulator NrdR -
  I2433_RS02000 (JDBNIEOD_00390) - 391100..392263 (+) 1164 WP_206152381.1 helicase loader -
  I2433_RS02005 (JDBNIEOD_00391) dnaI 392264..393172 (+) 909 WP_012516249.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26580.56 Da        Isoelectric Point: 4.6541

>NTDB_id=506355 I2433_RS01985 WP_012516253.1 388251..388937(+) (covR) [Streptococcus equi subsp. zooepidemicus strain SEZ14]
MTKKILIIEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKTPSQGVYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=506355 I2433_RS01985 WP_012516253.1 388251..388937(+) (covR) [Streptococcus equi subsp. zooepidemicus strain SEZ14]
ATGACAAAGAAAATTTTAATTATCGAAGATGAAAAGAATCTTGCAAGATTTGTTTCGCTTGAGCTACAACATGAGGGTTA
CGAGGTGACCGTCGAGGTTAATGGTCGTGAGGGCTTGGAGACAGCCCTAGAGAAGGACTTTGACTTAATCCTTCTTGATT
TGATGCTTCCTGAGATGGACGGATTTGAAGTGACACGTCGATTGCAAACAGAAAAAACGACTTACATCATGATGATGACT
GCGCGTGACTCTATTATGGACGTTGTAGCTGGCTTGGATCGTGGTGCTGACGATTACATCGTGAAGCCATTTGCCATTGA
GGAATTGCTGGCGCGTATTCGTGCTATCTTCCGTCGTCAGGACATTGAGTCAGAGAAAAAGACTCCTAGTCAAGGCGTTT
ACCGCGACTTAGTCTTAAACCCTCAAAACCGCTCTGTCAATCGCGGTGATGACGAGATTTCACTGACTAAGCGTGAATAT
GACCTGCTTAATATTTTGATGACAAACATGAATCGTGTCATGACTCGTGAGGAGCTCTTGTCTAACGTTTGGAAATATGA
CGAGGCTGTTGAAACTAACGTTGTTGATGTTTATATTCGTTACCTTCGTGGGAAGATAGATATCCCTGGGAAAGAGTCTT
ACATTCAAACTGTTCGTGGAATGGGTTATGTGATTCGCGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U5Y8A0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.533

100

0.829
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.401

99.561

0.671
  vicR Streptococcus mutans UA159

43.29

100

0.439
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425