Detailed information NTG0503579

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI20_RS08320
• Genome accession: NZ_CP064613
• Coordinates: 1671607..1672653 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG347
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1666607..1677653

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI20_RS08290 (HWI20_08205)	-	1666991..1668232 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI20_RS08295 (HWI20_08210)	-	1668234..1668449 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI20_RS08300 (HWI20_08215)	-	1668590..1669054 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI20_RS08305 (HWI20_08220)	-	1669062..1669346 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI20_RS08310 (HWI20_08225)	-	1669753..1670931 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI20_RS08315 (HWI20_08230)	vraR	1670988..1671617 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI20_RS08320 (HWI20_08235)	vraS	1671607..1672653 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI20_RS08325 (HWI20_08240)	liaF	1672650..1673351 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI20_RS08330 (HWI20_08245)	-	1673366..1673752 (-)	387	WP_001830382.1	hypothetical protein	-
HWI20_RS08335 (HWI20_08250)	map	1673910..1674665 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI20_RS08340 (HWI20_08255)	-	1674839..1675825 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI20_RS08345 (HWI20_08260)	isaB	1675976..1676512 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503579 HWI20_RS08320 WP_001830374.1 1671607..1672653(-) (vraS) [Staphylococcus epidermidis strain UMCG347]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503579 HWI20_RS08320 WP_001830374.1 1671607..1672653(-) (vraS) [Staphylococcus epidermidis strain UMCG347]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92