Detailed information NTG0503352

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI26_RS08320
• Genome accession: NZ_CP064590
• Coordinates: 1672996..1674042 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG353
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1667996..1679042

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI26_RS08290 (HWI26_08210)	-	1668380..1669621 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI26_RS08295 (HWI26_08215)	-	1669623..1669838 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI26_RS08300 (HWI26_08220)	-	1669979..1670443 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI26_RS08305 (HWI26_08225)	-	1670451..1670735 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI26_RS08310 (HWI26_08230)	-	1671142..1672320 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI26_RS08315 (HWI26_08235)	vraR	1672377..1673006 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI26_RS08320 (HWI26_08240)	vraS	1672996..1674042 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI26_RS08325 (HWI26_08245)	liaF	1674039..1674740 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI26_RS08330 (HWI26_08250)	-	1674755..1675141 (-)	387	WP_001830382.1	hypothetical protein	-
HWI26_RS08335 (HWI26_08255)	map	1675299..1676054 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI26_RS08340 (HWI26_08260)	-	1676228..1677214 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI26_RS08345 (HWI26_08265)	isaB	1677365..1677901 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503352 HWI26_RS08320 WP_001830374.1 1672996..1674042(-) (vraS) [Staphylococcus epidermidis strain UMCG353]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503352 HWI26_RS08320 WP_001830374.1 1672996..1674042(-) (vraS) [Staphylococcus epidermidis strain UMCG353]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92