Detailed information NTG0503239

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI29_RS08415
• Genome accession: NZ_CP064574
• Coordinates: 1769070..1770116 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG356
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1764070..1775116

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI29_RS08385 (HWI29_08310)	-	1764454..1765695 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI29_RS08390 (HWI29_08315)	-	1765697..1765912 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI29_RS08395 (HWI29_08320)	-	1766053..1766517 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI29_RS08400 (HWI29_08325)	-	1766525..1766809 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI29_RS08405 (HWI29_08330)	-	1767216..1768394 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI29_RS08410 (HWI29_08335)	vraR	1768451..1769080 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI29_RS08415 (HWI29_08340)	vraS	1769070..1770116 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI29_RS08420 (HWI29_08345)	liaF	1770113..1770814 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
HWI29_RS08425 (HWI29_08350)	-	1770829..1771215 (-)	387	WP_001830382.1	hypothetical protein	-
HWI29_RS08430 (HWI29_08355)	map	1771373..1772128 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI29_RS08435 (HWI29_08360)	-	1772302..1773288 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI29_RS08440 (HWI29_08365)	isaB	1773439..1773971 (-)	533	Protein_1640	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503239 HWI29_RS08415 WP_001830374.1 1769070..1770116(-) (vraS) [Staphylococcus epidermidis strain UMCG356]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503239 HWI29_RS08415 WP_001830374.1 1769070..1770116(-) (vraS) [Staphylococcus epidermidis strain UMCG356]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92