Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI31_RS03415 | Genome accession | NZ_CP064572 |
| Coordinates | 695042..695617 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG358 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 696018..738596 | 695042..695617 | flank | 401 |
Gene organization within MGE regions
Location: 695042..738596
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI31_RS03415 (HWI31_03375) | comK/comK1 | 695042..695617 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI31_RS03430 (HWI31_03390) | - | 696018..697067 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI31_RS03435 (HWI31_03395) | - | 697178..697375 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI31_RS03440 (HWI31_03400) | - | 697372..697779 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI31_RS03445 (HWI31_03405) | - | 697773..698210 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI31_RS03450 (HWI31_03410) | - | 698322..698990 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI31_RS03455 (HWI31_03415) | - | 699008..699466 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI31_RS03460 (HWI31_03420) | - | 699488..699802 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI31_RS03465 (HWI31_03425) | - | 699955..700167 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI31_RS03470 (HWI31_03430) | - | 700211..700351 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI31_RS03475 (HWI31_03435) | - | 700344..700568 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI31_RS03480 (HWI31_03440) | - | 700618..701358 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI31_RS03485 (HWI31_03445) | - | 701371..701580 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI31_RS03490 (HWI31_03450) | - | 701594..701740 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI31_RS03495 (HWI31_03455) | - | 701727..702005 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI31_RS03500 (HWI31_03460) | - | 702100..702276 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI31_RS03505 (HWI31_03465) | - | 702338..702589 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI31_RS03510 (HWI31_03470) | - | 702582..703067 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI31_RS03515 (HWI31_03475) | - | 703068..703694 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI31_RS03520 (HWI31_03480) | - | 703687..704103 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI31_RS03525 (HWI31_03485) | - | 704117..704806 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI31_RS03530 (HWI31_03490) | - | 704784..705014 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI31_RS03535 (HWI31_03495) | - | 705020..705235 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI31_RS03540 (HWI31_03500) | - | 705222..705950 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI31_RS03545 (HWI31_03505) | - | 705956..706309 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI31_RS03550 (HWI31_03510) | - | 706299..707546 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI31_RS03555 (HWI31_03515) | - | 707543..707773 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI31_RS03560 (HWI31_03520) | - | 707742..707966 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI31_RS03565 (HWI31_03525) | - | 707977..708393 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI31_RS03570 (HWI31_03530) | - | 708380..708754 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI31_RS03575 (HWI31_03535) | - | 708754..708945 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI31_RS03580 (HWI31_03540) | - | 708946..709305 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI31_RS03585 (HWI31_03545) | - | 709302..709754 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI31_RS03590 (HWI31_03550) | - | 709744..710031 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI31_RS03595 (HWI31_03555) | - | 710047..710727 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI31_RS03600 (HWI31_03560) | - | 710724..710924 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI31_RS03605 (HWI31_03565) | - | 710908..711261 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI31_RS03610 (HWI31_03570) | - | 711242..711439 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI31_RS03615 (HWI31_03575) | - | 711440..711967 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI31_RS03620 (HWI31_03580) | - | 712129..712287 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI31_RS03625 (HWI31_03585) | - | 712346..712624 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI31_RS03630 (HWI31_03590) | rinB | 712617..712784 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI31_RS03635 (HWI31_03595) | - | 712784..712933 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI31_RS03640 (HWI31_03600) | - | 712950..713396 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI31_RS03645 (HWI31_03605) | - | 713991..714341 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI31_RS03650 (HWI31_03610) | - | 714484..714954 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI31_RS03655 (HWI31_03615) | - | 714947..716698 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI31_RS03660 (HWI31_03620) | - | 716710..716904 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI31_RS03665 (HWI31_03625) | - | 716907..718139 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI31_RS03670 (HWI31_03630) | - | 718129..718686 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI31_RS03675 (HWI31_03635) | - | 718726..720075 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI31_RS03680 (HWI31_03640) | - | 720094..720435 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI31_RS03685 (HWI31_03645) | - | 720425..720754 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI31_RS03690 (HWI31_03650) | - | 720868..721155 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI31_RS03695 (HWI31_03655) | - | 721158..721562 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI31_RS03700 (HWI31_03660) | - | 721575..722204 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI31_RS03705 (HWI31_03665) | - | 722223..722408 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI31_RS03710 (HWI31_03670) | gpG | 722472..722834 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI31_RS03715 (HWI31_03675) | gpGT | 722879..723019 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI31_RS03720 (HWI31_03680) | - | 723048..727604 (+) | 4557 | Protein_719 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI31_RS03725 (HWI31_03685) | - | 727606..728439 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI31_RS03730 (HWI31_03690) | - | 728449..730008 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI31_RS03735 (HWI31_03695) | - | 730001..730174 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI31_RS03740 (HWI31_03700) | - | 730190..732052 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI31_RS03745 (HWI31_03705) | - | 732052..733266 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI31_RS03750 (HWI31_03710) | - | 733271..733894 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI31_RS03755 (HWI31_03715) | - | 733891..734316 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI31_RS03760 (HWI31_03720) | - | 734303..734710 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI31_RS03765 (HWI31_03725) | - | 734836..735102 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI31_RS03770 (HWI31_03730) | - | 735102..736484 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI31_RS03775 (HWI31_03735) | - | 736562..737488 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI31_RS03780 (HWI31_03740) | - | 737681..738208 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI31_RS03785 (HWI31_03745) | - | 738198..738596 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503184 HWI31_RS03415 WP_001829272.1 695042..695617(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG358]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503184 HWI31_RS03415 WP_001829272.1 695042..695617(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG358]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |