NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	IQS17_RS12105	Genome accession	NZ_CP063515
Coordinates	2466178..2467302 (-)	Length	374 a.a.
NCBI ID	WP_000228517.1	Uniprot ID	E2QFE2
Organism	Escherichia coli strain EH01-18-04-A
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	2463762..2473260	2466178..2467302	within	0

Gene organization within MGE regions

Location: 2463762..2473260

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IQS17_RS12085 (IQS17_12105)	aroE	2463762..2464580 (-)	819	WP_000451255.1	shikimate dehydrogenase	-
IQS17_RS12090 (IQS17_12110)	tsaC	2464585..2465157 (-)	573	WP_001296460.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
IQS17_RS12095 (IQS17_12115)	yrdD	2465162..2465704 (-)	543	WP_001296461.1	type I DNA topoisomerase	-
IQS17_RS12100 (IQS17_12120)	smg	2465733..2466206 (-)	474	WP_000460673.1	DUF494 family protein Smg	-
IQS17_RS12105 (IQS17_12125)	dprA	2466178..2467302 (-)	1125	WP_000228517.1	DNA-protecting protein DprA	Machinery gene
IQS17_RS12110 (IQS17_12130)	def	2467432..2467941 (+)	510	WP_000114984.1	peptide deformylase	-
IQS17_RS12115 (IQS17_12135)	fmt	2467956..2468903 (+)	948	WP_000004421.1	methionyl-tRNA formyltransferase	-
IQS17_RS12120 (IQS17_12140)	rsmB	2468955..2470244 (+)	1290	WP_000744765.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
IQS17_RS12125 (IQS17_12145)	trkA	2470266..2471642 (+)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
IQS17_RS12130 (IQS17_12150)	mscL	2471772..2472185 (+)	414	WP_000022450.1	large-conductance mechanosensitive channel protein MscL	-
IQS17_RS12135 (IQS17_12155)	arfA	2472182..2472400 (-)	219	WP_000092695.1	alternative ribosome-rescue factor ArfA	-
IQS17_RS12140 (IQS17_12160)	zntR	2472456..2472881 (-)	426	WP_000285610.1	Zn(2+)-responsive transcriptional regulator	-
IQS17_RS12145 (IQS17_12165)	yhdN	2472892..2473260 (-)	369	WP_000266504.1	DUF1992 domain-containing protein	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40910.86 Da Isoelectric Point: 6.0395

                                >NTDB_id=496015 IQS17_RS12105 WP_000228517.1 2466178..2467302(-) (dprA) [Escherichia coli strain EH01-18-04-A]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHAPLAASLLEQGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQEDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=496015 IQS17_RS12105 WP_000228517.1 2466178..2467302(-) (dprA) [Escherichia coli strain EH01-18-04-A]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGCATCAGCAGCTTGTATGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCATATTGATGCGGTTGTATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGCGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGTTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGATTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTTAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCTCCACTGGCTGCCAGTCTACT

TGAGCAAGGTGGTGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAGGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCTTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGGAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterproScan.

DprA winged helix domain (DprA_WH)

(312-357)

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	E2QFE2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.78	98.663	0.481
dprA	Vibrio cholerae strain A1552	49.355	82.888	0.409
dprA	Glaesserella parasuis strain SC1401	44.807	90.107	0.404
dprA	Haemophilus influenzae Rd KW20	44.214	90.107	0.398
dprA	Legionella pneumophila strain ERS1305867	44.242	88.235	0.39

Detailed information NTG0496015