Detailed information NTG0049304

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPNINV200_RS02475
• Genome accession: NC_017593
• Coordinates: 472323..473060 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219146.1
• Uniprot ID: A0A1C0UQ30
• Organism: Streptococcus pneumoniae INV200
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 467323..478060

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNINV200_RS12665	-	468253..468492 (-)	240	WP_001813906.1	hypothetical protein	-
SPNINV200_RS02445 (SPNINV200_04600)	-	468654..468941 (-)	288	WP_000777760.1	hypothetical protein	-
SPNINV200_RS02450 (SPNINV200_04610)	-	468951..469361 (-)	411	WP_001278301.1	HIT family protein	-
SPNINV200_RS02455 (SPNINV200_04620)	pptA	469429..470160 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
SPNINV200_RS02460 (SPNINV200_04630)	-	470157..471206 (+)	1050	WP_000653771.1	ABC transporter permease	-
SPNINV200_RS02465 (SPNINV200_04640)	-	471374..471703 (-)	330	WP_000132572.1	hypothetical protein	-
SPNINV200_RS02470 (SPNINV200_04650)	-	471980..472318 (+)	339	WP_000682132.1	LytTR family DNA-binding domain-containing protein	-
SPNINV200_RS02475 (SPNINV200_04660)	comE/blpR	472323..473060 (+)	738	WP_001219146.1	response regulator transcription factor	Regulator
SPNINV200_RS02480 (SPNINV200_04670)	-	473074..474414 (+)	1341	WP_001099895.1	sensor histidine kinase	-
SPNINV200_RS02485 (SPNINV200_04680)	blpC	474459..474614 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
SPNINV200_RS02490 (SPNINV200_04690)	-	474671..476032 (-)	1362	WP_001069098.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.87 Da
• Isoelectric Point: 6.0454

>NTDB_id=49304 SPNINV200_RS02475 WP_001219146.1 472323..473060(+) (comE/blpR) [Streptococcus pneumoniae INV200]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=49304 SPNINV200_RS02475 WP_001219146.1 472323..473060(+) (comE/blpR) [Streptococcus pneumoniae INV200]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A1C0UQ30

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363