Detailed information NTG0049234

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SPNOXC_RS04655
• Genome accession: NC_017592
• Coordinates: 868580..870820 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942414.1
• Uniprot ID: A0A4J1ZQU0
• Organism: Streptococcus pneumoniae OXC141
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 863580..875820

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNOXC_RS04615 (SPNOXC08520)	-	863731..864699 (+)	969	WP_000658183.1	PhoH family protein	-
SPNOXC_RS04620 (SPNOXC08530)	-	864892..865392 (+)	501	WP_000566982.1	GNAT family N-acetyltransferase	-
SPNOXC_RS04625 (SPNOXC08540)	-	865395..865720 (+)	326	Protein_890	TfoX/Sxy family protein	-
SPNOXC_RS13085 (SPNOXC08550)	ald	866021..867132 (-)	1112	Protein_891	alanine dehydrogenase	-
SPNOXC_RS04645 (SPNOXC08560)	-	867309..867878 (+)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
SPNOXC_RS04650 (SPNOXC08570)	comEA/celA/cilE	867946..868596 (+)	651	WP_000387335.1	helix-hairpin-helix domain-containing protein	Machinery gene
SPNOXC_RS04655 (SPNOXC08580)	comEC/celB	868580..870820 (+)	2241	WP_000942414.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SPNOXC_RS04660	-	870999..871187 (+)	189	WP_001809102.1	hypothetical protein	-
SPNOXC_RS04665 (SPNOXC08590)	-	871219..871806 (+)	588	WP_000933542.1	ABC transporter ATP-binding protein	-
SPNOXC_RS04670 (SPNOXC08600)	-	871810..872985 (+)	1176	WP_000655957.1	ABC transporter permease	-
SPNOXC_RS04675 (SPNOXC08610)	infC	873306..873836 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
SPNOXC_RS04680 (SPNOXC08620)	rpmI	873869..874069 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
SPNOXC_RS04685 (SPNOXC08630)	rplT	874121..874480 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
SPNOXC_RS04690 (SPNOXC08640)	-	874538..874918 (+)	381	WP_000157157.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84540.03 Da
• Isoelectric Point: 9.6773

>NTDB_id=49234 SPNOXC_RS04655 WP_000942414.1 868580..870820(+) (comEC/celB) [Streptococcus pneumoniae OXC141]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSTSYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFFTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGSKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=49234 SPNOXC_RS04655 WP_000942414.1 868580..870820(+) (comEC/celB) [Streptococcus pneumoniae OXC141]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
TTCAACATCCTATCTTGCTTTGTTGGGATTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTTACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCTCTAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (31-176)

• Competence protein (Competence) (216-458)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-697)

3D structure

• AlphaFold DB: A0A4J1ZQU0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae Rx1	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae D39	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae R6	96.649	100	0.966
comEC/celB	Streptococcus mitis SK321	92.359	100	0.924
comEC/celB	Streptococcus mitis NCTC 12261	92.081	99.866	0.92
comEC	Lactococcus lactis subsp. cremoris KW2	44.534	99.33	0.442