Detailed information NTG0048971

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: STH8232_RS01145
• Genome accession: NC_017581
• Coordinates: 203970..204719 (+)
• Length: 249 a.a.
• NCBI ID: WP_011680667.1
• Uniprot ID: Q03MN5
• Organism: Streptococcus thermophilus JIM 8232
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 198970..209719

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STH8232_RS11240 (STH8232_0246)	-	199546..199716 (+)	171	WP_011680664.1	hypothetical protein	-
STH8232_RS10175 (STH8232_0247)	-	199803..199910 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
STH8232_RS01130 (STH8232_0248)	-	199997..200737 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
STH8232_RS01135 (STH8232_0249)	-	200737..202287 (-)	1551	WP_011680665.1	ABC transporter substrate-binding protein/permease	-
STH8232_RS01140 (STH8232_0250)	-	202490..203344 (+)	855	WP_014621086.1	undecaprenyl-diphosphate phosphatase	-
STH8232_RS10180	-	203396..203704 (-)	309	WP_306496352.1	DUF3021 family protein	-
STH8232_RS01145 (STH8232_0252)	mecA	203970..204719 (+)	750	WP_011680667.1	adaptor protein MecA	Regulator
STH8232_RS01150 (STH8232_0253)	-	204723..205880 (+)	1158	WP_014621088.1	glycosyltransferase family 4 protein	-
STH8232_RS01155 (STH8232_0254)	sufC	206041..206811 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
STH8232_RS01160 (STH8232_0255)	sufD	206848..208110 (+)	1263	WP_014621089.1	Fe-S cluster assembly protein SufD	-
STH8232_RS01165 (STH8232_0256)	-	208164..209396 (+)	1233	WP_011680670.1	cysteine desulfurase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29174.68 Da
• Isoelectric Point: 4.0481

>NTDB_id=48971 STH8232_RS01145 WP_011680667.1 203970..204719(+) (mecA) [Streptococcus thermophilus JIM 8232]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=48971 STH8232_RS01145 WP_011680667.1 203970..204719(+) (mecA) [Streptococcus thermophilus JIM 8232]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

3D structure

• AlphaFold DB: Q03MN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMD-9	100	100	1
mecA	Streptococcus thermophilus LMG 18311	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.787	97.992	0.566
mecA	Streptococcus pneumoniae Rx1	46.586	100	0.466
mecA	Streptococcus pneumoniae D39	46.586	100	0.466
mecA	Streptococcus pneumoniae R6	46.586	100	0.466
mecA	Streptococcus pneumoniae TIGR4	46.586	100	0.466