Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   J7T63_RS08185 Genome accession   NZ_CP072442
Coordinates   1557368..1558735 (-) Length   455 a.a.
NCBI ID   WP_011681574.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain S24726     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1552368..1563735
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J7T63_RS08145 - 1552458..1552859 (-) 402 WP_024703992.1 hypothetical protein -
  J7T63_RS08150 (J7T63_08080) - 1553864..1554094 (-) 231 WP_260223024.1 bacteriocin class II family protein -
  J7T63_RS08155 (J7T63_08085) - 1554450..1554650 (-) 201 WP_011681569.1 hypothetical protein -
  J7T63_RS08160 (J7T63_08090) - 1554669..1554845 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  J7T63_RS08165 (J7T63_08095) - 1555096..1555833 (+) 738 WP_011681571.1 LytTR family DNA-binding domain-containing protein -
  J7T63_RS08170 - 1556364..1556981 (+) 618 WP_372429353.1 GHKL domain-containing protein -
  J7T63_RS08175 - 1556899..1557174 (+) 276 WP_372429355.1 GHKL domain-containing protein -
  J7T63_RS08180 (J7T63_08105) - 1557192..1557353 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  J7T63_RS08185 (J7T63_08110) comB 1557368..1558735 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein Regulator
  J7T63_RS08190 (J7T63_08115) - 1558751..1560903 (-) 2153 Protein_1561 peptide cleavage/export ABC transporter -
  J7T63_RS08195 (J7T63_08125) - 1561917..1563662 (-) 1746 WP_372429357.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 455 a.a.        Molecular weight: 50382.07 Da        Isoelectric Point: 4.7492

>NTDB_id=483527 J7T63_RS08185 WP_011681574.1 1557368..1558735(-) (comB) [Streptococcus thermophilus strain S24726]
MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEVTVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKV
VKKGDTLVQYSETMEASQKEGLQKQLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKT
NTEVNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQYATTPDASVTDQYLSQVN
TNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQFLQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPED
GILHLSQADKKATMAATGTELAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSAT
ETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ

Nucleotide


Download         Length: 1368 bp        

>NTDB_id=483527 J7T63_RS08185 WP_011681574.1 1557368..1558735(-) (comB) [Streptococcus thermophilus strain S24726]
ATGAATCCACAGTTGTTTAAAAGCACAGAGTTTTACCATCGTCGCTACCACAATATGTCTACTGTTTTGATTACTCCCTT
GATTTTGTTAGTTATTTTCCTTTTTCTTTTCGCTTTTTTTGCTAAGAAGGAAGTTACAGTCACGTCTAGAGGAAGTATAG
AGCCAACCAAGGTTATCGCAGTAATCCAATCAACCAGTGACAATACCATCATAGATAATCAACTGGTTGCTAATAAGGTT
GTTAAAAAAGGGGACACCTTAGTTCAGTATTCAGAGACCATGGAGGCATCGCAAAAAGAGGGGCTTCAAAAGCAACTAGA
ACTTTTAAAAAGACAGGAATCAGGTTTGAAGACCTTGCAATCTAGCCTAACGCAGGGAACCAATCTTTTCCAAGAACAGG
AAGACGAGTTTGGTTATCAGAGTACTTTTAACACCTACCTAAGTCAGGCACAGGATATTGACTTGGGTGTGGCTAAAACA
AATACAGAGGTTAATAACCAAGCAGCAATTGCGAGTAATACCGGTTCTGCTATTGATAACCAGATTAGTCAATTGCAGAC
TCAGGTCTCAGAGTATGAGGCGCTCTCTCAAGCTATTACCAATCATGAAACGACTTTACCTGAAGGCAATCCTCATCAGG
CAACCTTAAATGCCTATAACAGTCAGTATGCTACGACACCGGATGCCAGTGTAACAGACCAATACCTATCTCAAGTTAAT
ACCAATATTTCGAGCTTGAATGCTTCCATAGGTAATCTAGAAATCCAAAAGGCTGGGACAGGCACAGTTGTAACTTATGA
CAATAGTGATAGCACTAAAAAAGAAGCTCTAAAAAATCAATTCTTGCAAAATGCAGGACAGCAATTGAGCTCAGTGGAAA
CACAAATTAACGATACCGAGAGTAAAATCAATCAGGCAGATGTCCTTCTGACTAATACCCTCATCCAGTCACCAGAAGAT
GGAATCTTACACTTGAGTCAAGCTGATAAAAAAGCAACCATGGCTGCGACAGGAACTGAGTTGGCCCAGCTTTATCCCGA
TATGACTCAAACCCAGGAAGTTGCCATTACTTATTATGTGAATTCGGATTATGTGCCAAAACTGCAAAAAGGCCAGTCAG
TTCGACTGACCTTGGATAAGGTTGGTAATCACGGTACCACAATTATTGGAAAACTTGAGAGTATTGATAATTCTGCCACG
GAAACAGAAAGGGGGAATGTGTTTAGAGTAACTGCTAGGGCAAGTATTTCAGAAAAAGAAGCCCAAAATCTACGTTACGG
TCTAGAAGGTCGTGTGACAAGCGTTATTGACCAAAAGACCTACTTCAATTACTTTAAAGACAAGTTACTAAACTTGCAAG
ACCAATAG

Domains

Predicted by InterProScan.

HlyD family secretion protein ()

(315-427)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae Rx1

39.468

99.121

0.391
  comB Streptococcus pneumoniae D39

39.468

99.121

0.391
  comB Streptococcus pneumoniae R6

39.468

99.121

0.391
  comB Streptococcus pneumoniae TIGR4

38.803

99.121

0.385
  comB Streptococcus mitis SK321

38.137

99.121

0.378
  comB Streptococcus mitis NCTC 12261

38.137

99.121

0.378