NTDB

Overview

Name	comYH	Type	Machinery gene
Locus tag	D39N_RS09280	Genome accession	NZ_CP061208
Coordinates	1837991..1838944 (-)	Length	317 a.a.
NCBI ID	WP_000345135.1	Uniprot ID	A0A2U3RW99
Organism	Streptococcus pneumoniae strain D39_P0
Function	dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1832991..1843944

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D39N_RS09255 (D39N_01857)	-	1833752..1834375 (-)	624	WP_000932644.1	hypothetical protein	-
D39N_RS09260 (D39N_01858)	jag	1834426..1835412 (-)	987	WP_000260012.1	RNA-binding cell elongation regulator Jag/EloR	-
D39N_RS09265 (D39N_01859)	-	1835431..1836255 (-)	825	WP_000727904.1	membrane protein insertase YidC	-
D39N_RS09270 (D39N_01860)	rnpA	1836230..1836601 (-)	372	WP_000739246.1	ribonuclease P protein component	-
D39N_RS10860	-	1836618..1836749 (-)	132	WP_000768904.1	hypothetical protein	-
D39N_RS09275 (D39N_01861)	-	1836750..1837940 (-)	1191	WP_000167757.1	acetate kinase	-
D39N_RS09280 (D39N_01862)	comYH	1837991..1838944 (-)	954	WP_000345135.1	class I SAM-dependent methyltransferase	Machinery gene
D39N_RS09285	-	1839005..1839599 (-)	595	Protein_1833	methyltransferase domain-containing protein	-
D39N_RS09290 (D39N_01865)	comGG/cglG	1839736..1840149 (-)	414	WP_000265622.1	competence type IV pilus minor pilin ComGG	Machinery gene
D39N_RS09295 (D39N_01866)	comGF/cglF	1840127..1840588 (-)	462	WP_000250534.1	competence type IV pilus minor pilin ComGF	Machinery gene
D39N_RS09300 (D39N_01867)	comGE/cglE	1840551..1840853 (-)	303	WP_000413382.1	competence type IV pilus minor pilin ComGE	Machinery gene
D39N_RS09305 (D39N_01868)	comGD/cglD	1840816..1841220 (-)	405	WP_000588026.1	competence type IV pilus minor pilin ComGD	Machinery gene
D39N_RS09310 (D39N_01869)	comGC/cglC	1841213..1841539 (-)	327	WP_000738626.1	comG operon protein ComGC	Machinery gene
D39N_RS09315 (D39N_01870)	comGB/cglB	1841541..1842557 (-)	1017	WP_074196785.1	competence type IV pilus assembly protein ComGB	Machinery gene
D39N_RS09320 (D39N_01871)	comGA/cglA/cilD	1842505..1843446 (-)	942	WP_000249564.1	competence type IV pilus ATPase ComGA	Machinery gene
D39N_RS09325 (D39N_01872)	-	1843522..1843887 (-)	366	WP_000286412.1	DUF1033 family protein	-

Sequence

Protein

Download Length: 317 a.a. Molecular weight: 35756.99 Da Isoelectric Point: 4.2748

                                >NTDB_id=481427 D39N_RS09280 WP_000345135.1 1837991..1838944(-) (comYH) [Streptococcus pneumoniae strain D39_P0]

MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKENNQTLKRLALRKEEWLKTYQFLLMKAGQT

EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGAIFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ

AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ

SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

Nucleotide

Download Length: 954 bp

                                >NTDB_id=481427 D39N_RS09280 WP_000345135.1 1837991..1838944(-) (comYH) [Streptococcus pneumoniae strain D39_P0]

ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA

CTTTTATGACGCCTTGGTGGAGCAAAATAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAGGAGAACAATC

AAACCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA

GAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA

AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTATTTTCTTGACCTCGCTTACTAAAA

AGGTGGATTACTTGGGAATGGAAGTGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG

GCTGGCTTTGTCCAAGGAGATGCCGTTCGCCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTCGG

CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA

TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA

AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAA

TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA

GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(69-282)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A2U3RW99

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comYH	Streptococcus mutans UA140	54.633	98.738	0.539
comYH	Streptococcus mutans UA159	54.313	98.738	0.536

Detailed information NTG0481427