Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   IB936_RS02305 Genome accession   NZ_CP061133
Coordinates   439506..440858 (+) Length   450 a.a.
NCBI ID   WP_002990673.1    Uniprot ID   A0A660A508
Organism   Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 434506..445858
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB936_RS02280 (IB936_02280) - 434660..435229 (+) 570 WP_021299212.1 hypothetical protein -
  IB936_RS02285 (IB936_02285) - 435198..436347 (+) 1150 Protein_414 acetyl-CoA C-acyltransferase -
  IB936_RS02290 (IB936_02290) - 436304..437551 (+) 1248 WP_011528374.1 AMP-binding protein -
  IB936_RS02295 (IB936_02295) - 437607..438641 (+) 1035 WP_011528375.1 DUF3114 domain-containing protein -
  IB936_RS02300 (IB936_02300) vicR 438803..439513 (+) 711 WP_002985645.1 response regulator YycF Regulator
  IB936_RS02305 (IB936_02305) vicK 439506..440858 (+) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  IB936_RS02310 (IB936_02310) vicX 440862..441671 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  IB936_RS02315 (IB936_02315) rnc 442114..442806 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 450 a.a.        Molecular weight: 51391.82 Da        Isoelectric Point: 5.4026

>NTDB_id=480924 IB936_RS02305 WP_002990673.1 439506..440858(+) (vicK) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide


Download         Length: 1353 bp        

>NTDB_id=480924 IB936_RS02305 WP_002990673.1 439506..440858(+) (vicK) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGTTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTTT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

PAS fold (PAS)

(95-162)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-436)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A508

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

72.705

92

0.669
  micB Streptococcus pneumoniae Cp1015

67.765

94.444

0.64